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NF1
Description
neurofibromin 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleolus
Cytoplasm
Cytosol
Membrane
Axon
Dendrite
Presynapse
Molecular Function
GTPase Activator Activity
Protein Binding
Phosphatidylethanolamine Binding
Phosphatidylcholine Binding
Biological Process
MAPK Cascade
Osteoblast Differentiation
Metanephros Development
Response To Hypoxia
Liver Development
Negative Regulation Of Endothelial Cell Proliferation
Positive Regulation Of Endothelial Cell Proliferation
Regulation Of Cell-matrix Adhesion
Negative Regulation Of Cell-matrix Adhesion
Negative Regulation Of Protein Kinase Activity
Cell Communication
Ras Protein Signal Transduction
Negative Regulation Of Neuroblast Proliferation
Brain Development
Peripheral Nervous System Development
Heart Development
Skeletal Muscle Tissue Development
Visual Learning
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of Gene Expression
Schwann Cell Development
Phosphatidylinositol 3-kinase Signaling
Negative Regulation Of Angiogenesis
Spinal Cord Development
Amygdala Development
Forebrain Astrocyte Development
Neural Tube Development
Cerebral Cortex Development
Myelination In Peripheral Nervous System
Actin Cytoskeleton Organization
Extracellular Matrix Organization
Collagen Fibril Organization
Adrenal Gland Development
Negative Regulation Of Cell Migration
Regulation Of Synaptic Transmission, GABAergic
Cellular Response To Heat
Negative Regulation Of Rac Protein Signal Transduction
Wound Healing
Negative Regulation Of Protein Import Into Nucleus
Positive Regulation Of Apoptotic Process
Regulation Of GTPase Activity
Negative Regulation Of MAP Kinase Activity
Negative Regulation Of MAPK Cascade
Pigmentation
Positive Regulation Of Neuron Apoptotic Process
Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of GTPase Activity
Regulation Of Bone Resorption
Negative Regulation Of Osteoclast Differentiation
Regulation Of Glial Cell Differentiation
Positive Regulation Of Adenylate Cyclase Activity
Regulation Of Angiogenesis
Negative Regulation Of Neurotransmitter Secretion
Negative Regulation Of Fibroblast Proliferation
Regulation Of Long-term Neuronal Synaptic Plasticity
Sympathetic Nervous System Development
Camera-type Eye Morphogenesis
Negative Regulation Of Astrocyte Differentiation
Negative Regulation Of Oligodendrocyte Differentiation
Smooth Muscle Tissue Development
Hair Follicle Maturation
Artery Morphogenesis
Forebrain Morphogenesis
Cognition
Gamma-aminobutyric Acid Secretion, Neurotransmission
Glutamate Secretion, Neurotransmission
Observational Learning
Regulation Of Long-term Synaptic Potentiation
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Regulation of RAS by GAPs
RAS signaling downstream of NF1 loss-of-function variants
Drugs
Diseases
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS
Adventurousness (
30643258
)
Bitter alcoholic beverage consumption (
31046077
)
Endometrial cancer (
30093612
)
Endometrial cancer (endometrioid histology) (
30093612
)
Familial squamous cell lung carcinoma (
29924316
)
Feeling nervous (
29500382
)
General risk tolerance (MTAG) (
30643258
)
Hip circumference (
25673412
)
Hip circumference adjusted for BMI (
28552196
)
Total cholesterol levels (
29083408
)
Type 2 diabetes (
30297969
)
Interacting Genes
16 interacting genes:
AKT1
APP
CLK1
DNAJC7
EPHA2
GRIN1
GRIN2D
HRAS
HTR6
LIMK2
MAP2K3
RAF1
SDC2
SOX4
TBPL1
VCP
Entrez ID
4763
HPRD ID
01203
Ensembl ID
ENSG00000196712
Uniprot IDs
P21359
PDB IDs
1NF1
2D4Q
2E2X
3P7Z
3PEG
3PG7
6OB2
6OB3
Enriched GO Terms of Interacting Partners
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