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MPL

Description MPL proto-oncogene, thrombopoietin receptor
Image No pdb structure
GO Annotations Cellular Component
  • Golgi Apparatus
  • Plasma Membrane
  • Cell Surface
  • Integral Component Of Membrane
  • Nuclear Membrane
  • Neuron Projection
  • Neuronal Cell Body
Molecular Function
  • Protein Binding
  • Thrombopoietin Receptor Activity
Biological Process
  • Neutrophil Homeostasis
  • Monocyte Homeostasis
  • Thrombopoietin-mediated Signaling Pathway
  • Positive Regulation Of Lymphocyte Proliferation
  • Platelet Aggregation
  • Cellular Response To Hypoxia
  • Positive Regulation Of Platelet Formation
  • Eosinophil Homeostasis
  • Basophil Homeostasis
Pathways
  • Platelet Aggregation (Plug Formation)
Drugs
  • Romiplostim
  • SB-559448
  • Eltrombopag
Diseases
  • Congenital amegakaryocytic thrombocytopenia (CAMT)
GWAS
Interacting Genes 9 interacting genes: ANKRA2 ATXN2L IRS2 JAK2 PTPN11 SHC1 SOCS1 THPO YWHAQ
Entrez ID 4352
HPRD ID 01161
Ensembl ID ENSG00000117400
Uniprot IDs P40238
PDB IDs
Enriched GO Terms of Interacting Partners?
Tagcloud ?

© Madhavi K. Ganapathiraju 2012-2025

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