LIF

Description		LIF interleukin 6 family cytokine
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol
	Molecular Function	Signaling Receptor Binding Cytokine Activity Leukemia Inhibitory Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Blood Vessel Remodeling Immune Response Tyrosine Phosphorylation Of STAT Protein Multicellular Organism Development Embryo Implantation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Stem Cell Population Maintenance Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Positive Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of MAPK Cascade Regulation Of Cell Differentiation Positive Regulation Of Macrophage Differentiation Negative Regulation Of Meiotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Decidualization Negative Regulation Of Hormone Secretion Lung Alveolus Development Muscle Organ Morphogenesis Neuron Development Positive Regulation Of Astrocyte Differentiation Leukemia Inhibitory Factor Signaling Pathway Stem Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Lung Vasculature Development Lung Lobe Morphogenesis Trophoblast Giant Cell Differentiation Spongiotrophoblast Differentiation Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Histone H3-K27 Acetylation Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
Pathways		Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions
Drugs
Diseases
GWAS		Delirium ( 29631748) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 23128233) Inflammatory bowel disease (early onset) ( 19915574) Nephropathy ( 21399633) Tonsillectomy ( 27941131)
Interacting Genes		2 interacting genes: IL6ST LIFR
Entrez ID		3976
HPRD ID		08869
Ensembl ID		ENSG00000128342
Uniprot IDs		P15018
PDB IDs		1EMR 1PVH 2Q7N
Enriched GO Terms of Interacting Partners?
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