ITPR2

Description		inositol 1,4,5-trisphosphate receptor type 2
Image		No pdb structure
GO Annotations	Cellular Component	Cell Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Cell Cortex Membrane Integral Component Of Membrane Sarcoplasmic Reticulum Cytoplasmic Vesicle Membrane Secretory Granule Membrane Platelet Dense Tubular Network Membrane Sarcoplasmic Reticulum Membrane Receptor Complex
	Molecular Function	Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Calcium Ion Binding Calcium Ion Transmembrane Transporter Activity Phosphatidylinositol Binding Ion Channel Binding Inositol 1,4,5 Trisphosphate Binding Scaffold Protein Binding
	Biological Process	Response To Hypoxia Signal Transduction Platelet Activation Inositol Phosphate-mediated Signaling Regulation Of Insulin Secretion Release Of Sequestered Calcium Ion Into Cytosol Cellular Response To CAMP Cellular Response To Ethanol Regulation Of Cardiac Conduction
Pathways		PLC beta mediated events Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels DAG and IP3 signaling Role of phospholipids in phagocytosis FCERI mediated Ca+2 mobilization Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Ca2+ pathway Regulation of insulin secretion VEGFR2 mediated cell proliferation Ion homeostasis Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		Caffeine
Diseases
GWAS		Amyotrophic lateral sclerosis ( 17827064) Birth weight ( 31043758 27680694) BRCA1/2-negative high-risk breast cancer ( 30323354) Heel bone mineral density ( 30598549) Kashin-Beck disease ( 25303641) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Major depressive disorder ( 27479909) Male-pattern baldness ( 27182965) Offspring birth weight ( 31043758) Renal cell carcinoma ( 31231134 22010048) Smooth-surface caries ( 24556642) Type 2 diabetes ( 30054458 30297969) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500) Waist-hip ratio ( 25673412 20935629) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		5 interacting genes: BANK1 PKP2 PRKACA TRPC1 TRPC4
Entrez ID		3709
HPRD ID		02536
Ensembl ID		ENSG00000123104
Uniprot IDs		Q14571
PDB IDs
Enriched GO Terms of Interacting Partners?
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