IFNG

Description		interferon gamma
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Activity Interferon-gamma Receptor Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Microglial Cell Activation Positive Regulation Of Protein Phosphorylation Adaptive Immune Response Apoptotic Process Humoral Immune Response Cell Cycle Arrest Cell Surface Receptor Signaling Pathway JAK-STAT Cascade Positive Regulation Of Cell Proliferation Response To Virus Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Regulation Of Protein ADP-ribosylation Positive Regulation Of Receptor Biosynthetic Process Negative Regulation Of Epithelial Cell Differentiation Positive Regulation Of Protein Complex Assembly Negative Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Involved In Immune Response Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Positive Regulation Of Smooth Muscle Cell Apoptotic Process Interleukin-12-mediated Signaling Pathway Regulation Of Growth Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Chemokine Biosynthetic Process Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Glycolytic Process Negative Regulation Of Transcription, DNA-templated Astrocyte Activation Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Interleukin-1 Beta Biosynthetic Process Positive Regulation Of Phagocytosis Positive Regulation Of Neurogenesis Regulation Of Insulin Secretion Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Nitrogen Compound Metabolic Process Defense Response To Virus Positive Regulation Of Killing Of Cells Of Other Organism Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Fructose 1,6-bisphosphate 1-phosphatase Activity Positive Regulation Of Fructose 1,6-bisphosphate Metabolic Process Positive Regulation Of Vitamin D Biosynthetic Process Positive Regulation Of Calcidiol 1-monooxygenase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Deacetylation Extrinsic Apoptotic Signaling Pathway Neuroinflammatory Response Negative Regulation Of Amyloid-beta Clearance Positive Regulation Of Neuron Death Positive Regulation Of Cellular Respiration Positive Regulation Of Amyloid-beta Formation Negative Regulation Of Tau-protein Kinase Activity Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Exosomal Secretion Positive Regulation Of Ferrous Iron Import Across Plasma Membrane Positive Regulation Of Tumor Necrosis Factor Secretion Positive Regulation Of NMDA Glutamate Receptor Activity Positive Regulation Of Core Promoter Binding Positive Regulation Of Tumor Necrosis Factor (ligand) Superfamily Member 11 Production
Pathways		Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs		Olsalazine Glucosamine VIR201 Fontolizumab Apremilast
Diseases		Graft-versus-host disease Allograft rejection
GWAS		Alopecia areata ( 25608926) Anti-saccade response ( 29064472) Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Systemic lupus erythematosus ( 28714469) Ulcerative colitis ( 20228799 21297633 19122664)
Interacting Genes		5 interacting genes: IFNGR1 IFNGR2 PDIA3 STAT6 TNF
Entrez ID		3458
HPRD ID		00957
Ensembl ID		ENSG00000111537
Uniprot IDs		P01579
PDB IDs		1EKU 1FG9 1FYH 1HIG 3BES 6E3K 6E3L
Enriched GO Terms of Interacting Partners?
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