IFI16

Description		interferon gamma inducible protein 16
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Membrane Nuclear Speck
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Double-stranded DNA Binding RNA Binding Protein Binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cytokine Production Activation Of Innate Immune Response Autophagy Inflammatory Response Regulation Of Autophagy Myeloid Cell Differentiation Monocyte Differentiation Positive Regulation Of Type I Interferon Production Positive Regulation Of Interleukin-1 Beta Production Cellular Response To Interferon-beta Regulation Of Gene Expression, Epigenetic Cellular Response To Glucose Starvation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of DNA Binding Negative Regulation Of Viral Genome Replication Innate Immune Response Negative Regulation Of Innate Immune Response Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Cellular Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Activation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Cysteine-type Endopeptidase Activity
Pathways		STING mediated induction of host immune responses IRF3-mediated induction of type I IFN
Drugs
Diseases
GWAS		Blood protein levels ( 29875488) C-reactive protein ( 22939635) Celiac disease or Rheumatoid arthritis ( 21383967) Neutrophil count in HIV-infection ( 25884002) Obesity-related traits ( 23251661) Periodontal disease-related phenotype (Socransky) ( 26962152)
Interacting Genes		11 interacting genes: APP AR AURKA BRCA1 CSNK2A1 ID1 ID2 ID3 TP53 TP53BP1 TPR
Entrez ID		3428
HPRD ID		00969
Ensembl ID		ENSG00000163565
Uniprot IDs		Q16666
PDB IDs		2OQ0 3B6Y 3RLN 3RLO 3RNU 4QGU
Enriched GO Terms of Interacting Partners?
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