CFI

Description		complement factor I
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Membrane Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Scavenger Receptor Activity Protein Binding Metal Ion Binding
	Biological Process	Proteolysis Endocytosis Complement Activation, Classical Pathway Viral Process Regulation Of Complement Activation Innate Immune Response
Pathways		Regulation of Complement cascade
Drugs		Zinc Copper
Diseases		Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 20385826 23455636 21665990) Age-related macular degeneration (geographic atrophy) ( 22705344) Blood protein levels ( 30072576 29875488 28240269) Fasting insulin (dietary factor interaction) ( 24204828) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245)
Interacting Genes		3 interacting genes: C3 CFH GLP1R
Entrez ID		3426
HPRD ID		01955
Ensembl ID		ENSG00000205403
Uniprot IDs		A8K3L0 B4DRF2 G3XAM2 P05156 Q8WW88
PDB IDs		2XRC 5O32
Enriched GO Terms of Interacting Partners?
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