AIRE

Description		autoimmune regulator
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GO Annotations	Cellular Component	Nucleus Cytoplasm Nuclear Body
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding Identical Protein Binding Transcription Regulatory Region DNA Binding Translation Regulator Activity
	Biological Process	Peripheral T Cell Tolerance Induction Central Tolerance Induction To Self Antigen Regulation Of Transcription, DNA-templated Regulation Of Translation Immune Response Humoral Immune Response Chemokine Production Negative Thymic T Cell Selection Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Thymus Epithelium Morphogenesis Regulation Of Thymocyte Migration
Pathways
Drugs
Diseases		Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS		Dental caries (decayed, missing and filled teeth) ( 31533690) Rheumatoid arthritis ( 21505073 30423114)
Interacting Genes		5 interacting genes: CREBBP DAXX H2BC21 H3C1 UBAC1
Entrez ID		326
HPRD ID		06301
Ensembl ID		ENSG00000160224
Uniprot IDs		O43918
PDB IDs		1XWH 2KE1 2KFT 2LRI
Enriched GO Terms of Interacting Partners?
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