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SENP1

Description SUMO specific peptidase 1
Image
GO Annotations Cellular Component
  • Nucleus
  • Nucleoplasm
  • Cytoplasm
  • Focal Adhesion
  • Nuclear Membrane
Molecular Function
  • Endopeptidase Activity
  • Protein Binding
  • SUMO-specific Protease Activity
  • SUMO-specific Isopeptidase Activity
Biological Process
  • Proteolysis
  • Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
  • Regulation Of Definitive Erythrocyte Differentiation
  • Protein Sumoylation
  • Protein Desumoylation
  • Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
  • Positive Regulation Of Transcription By RNA Polymerase II
  • Apoptotic Signaling Pathway
Pathways
  • SUMO is proteolytically processed
Drugs
Diseases
GWAS
  • Glycated hemoglobin levels ( 28898252)
  • Macular thickness ( 30535121)
  • Rheumatoid arthritis ( 30891314)
Interacting Genes 23 interacting genes: APP CAV3 GCM1 HDAC1 HIPK2 KCNK1 NACC1 PARP1 PIAS3 PIM1 PML PRIM1 RABGAP1 RANBP2 RANGAP1 RPL11 SP100 SUMO1 SUMO2 SUMO3 UBE2K USP25 USP28
Entrez ID 29843
HPRD ID 07153
Ensembl ID ENSG00000079387
Uniprot IDs Q6N001 Q7Z3G1 Q9P0U3
PDB IDs 2CKG 2CKH 2G4D 2IY0 2IY1 2IYC 2IYD 2XPH 2XRE 6NNQ
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2025

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