GMDS

Description		GDP-mannose 4,6-dehydratase
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GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding GDP-mannose 4,6-dehydratase Activity Identical Protein Binding NADP+ Binding
	Biological Process	Notch Signaling Pathway GDP-mannose Metabolic Process 'de Novo' GDP-L-fucose Biosynthetic Process
Pathways		GDP-fucose biosynthesis
Drugs		Guanosine-5'-Diphosphate-Rhamnose Guanosine-5'-Diphosphate
Diseases
GWAS		Anthropometric traits (multi-trait analysis) ( 30166351) Caudate nucleus volume ( 21502949) Coronary artery disease ( 29212778) Daytime sleep phenotypes ( 27126917) Fish intake frequency ( 31320941) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 29891935 25173105) Heel bone mineral density ( 30598549) Height ( 31562340) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hip circumference adjusted for BMI ( 25673412) Impulsivity (non-planning) ( 30718321) Intraocular pressure ( 29617998 29785010 31959993 30054594) Iris heterochromicity ( 30895295) Late-onset myasthenia gravis ( 26562150) Medication use (diuretics) ( 31015401) Monobrow ( 27182965) Monobrow thickness ( 26926045) Obesity-related traits ( 23251661) Optic disc size ( 31809533) Pulse pressure ( 30578418) Red blood cell count ( 27863252) Response to platinum-based agents ( 22020760) Sub-cortical grey matter volume ( 31530798) Urate levels ( 31578528) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		1 interacting genes: NTAQ1
Entrez ID		2762
HPRD ID		11925
Ensembl ID		ENSG00000112699
Uniprot IDs		O60547
PDB IDs		1T2A 5IN4 5IN5 6GPJ 6GPK 6GPL 6Q94
Enriched GO Terms of Interacting Partners?
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