GPC3

Description		glypican 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Intrinsic Component Of Plasma Membrane Lysosomal Lumen Anchored Component Of Plasma Membrane Collagen-containing Extracellular Matrix
	Molecular Function	Protein Binding Peptidyl-dipeptidase Inhibitor Activity
	Biological Process	Retinoid Metabolic Process Branching Involved In Ureteric Bud Morphogenesis Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Response To Bacterium Anatomical Structure Morphogenesis Anterior/posterior Axis Specification Body Morphogenesis Negative Regulation Of Peptidase Activity Cell Migration Bone Mineralization Osteoclast Differentiation Lung Development Positive Regulation Of BMP Signaling Pathway Embryonic Hindlimb Morphogenesis Cell Migration Involved In Gastrulation Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Endocytosis Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of Smoothened Signaling Pathway Negative Regulation Of Growth Positive Regulation Of Glucose Import Negative Regulation Of Epithelial Cell Proliferation Regulation Of Canonical Wnt Signaling Pathway Coronary Vasculature Development Cell Proliferation Involved In Kidney Development Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Mesonephric Duct Morphogenesis Cell Proliferation Involved In Metanephros Development Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Localization To Membrane Regulation Of Non-canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways		A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Defective B3GALT6 causes EDSP2 and SEMDJL1 Post-translational protein phosphorylation Retinoid metabolism and transport
Drugs
Diseases		Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses
GWAS		Educational attainment (years of education) ( 30038396) Relative hand skill ( 24068947)
Interacting Genes		5 interacting genes: FGF2 IGF2 PTPRS WNT3A WNT7B
Entrez ID		2719
HPRD ID		02074
Ensembl ID		ENSG00000147257
Uniprot IDs		B4DTD8 I6QTG3 P51654 Q53H15
PDB IDs
Enriched GO Terms of Interacting Partners?
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