GAS6

Description		growth arrest specific 6
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Platelet Alpha Granule Lumen Extracellular Exosome
	Molecular Function	Phosphatidylserine Binding Signaling Receptor Binding Calcium Ion Binding Protein Binding Protein Tyrosine Kinase Activator Activity Protein Binding, Bridging Receptor Tyrosine Kinase Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Receptor Ligand Activity
	Biological Process	Neuron Migration Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cytokine-mediated Signaling Pathway Platelet Degranulation Positive Regulation Of Glomerular Filtration Protein Phosphorylation ER To Golgi Vesicle-mediated Transport Phagocytosis Apoptotic Process Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Blood Coagulation Cellular Response To Starvation Positive Regulation Of Gene Expression Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Macrophage Cytokine Production Peptidyl-serine Phosphorylation Fusion Of Virus Membrane With Host Plasma Membrane Viral Genome Replication Animal Organ Regeneration Cell-substrate Adhesion Positive Regulation Of TOR Signaling Activation Of Protein Kinase B Activity Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Interferon-alpha Cellular Response To Drug B Cell Chemotaxis Regulation Of Growth Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Apoptotic Cell Clearance Negative Regulation Of DNA-binding Transcription Factor Activity Protein Kinase B Signaling Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Fibroblast Proliferation Negative Regulation Of Interleukin-1 Secretion Positive Regulation Of Phagocytosis Leukocyte Migration Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Biomineral Tissue Development Positive Regulation Of ERK1 And ERK2 Cascade Calcium Ion Transmembrane Transport Cellular Response To Vitamin K Cellular Response To Glucose Stimulus Cellular Response To Growth Factor Stimulus Protein Localization To Plasma Membrane Extracellular Matrix Assembly Dendritic Cell Differentiation Hematopoietic Stem Cell Migration To Bone Marrow Negative Regulation Of Oligodendrocyte Apoptotic Process Negative Regulation Of Interleukin-6 Secretion Negative Regulation Of Fibroblast Apoptotic Process Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Dendritic Cell Chemotaxis Negative Regulation Of Renal Albumin Absorption Negative Regulation Of Dendritic Cell Apoptotic Process
Pathways		Platelet degranulation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Glycated hemoglobin levels ( 28898252) LDL cholesterol ( 30275531) Red blood cell count ( 27863252) Red cell distribution width ( 27863252) Total cholesterol levels ( 29083408) Triglycerides ( 30275531 27036123)
Interacting Genes		3 interacting genes: AXL MERTK TYRO3
Entrez ID		2621
HPRD ID		02705
Ensembl ID		ENSG00000183087
Uniprot IDs		Q14393
PDB IDs		1H30 2C5D 4RA0 5VXZ
Enriched GO Terms of Interacting Partners?
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