FGF9

Description		fibroblast growth factor 9
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GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Cytoplasm
	Molecular Function	Fibroblast Growth Factor Receptor Binding Growth Factor Activity Heparin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Angiogenesis Osteoblast Differentiation Eye Development Positive Regulation Of Mesenchymal Cell Proliferation Chondrocyte Differentiation Protein Import Into Nucleus Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Male Gonad Development Positive Regulation Of Gene Expression Substantia Nigra Development Negative Regulation Of Wnt Signaling Pathway Male Sex Determination Embryonic Limb Morphogenesis Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Inner Ear Morphogenesis Positive Regulation Of MAPK Cascade Positive Regulation Of Smoothened Signaling Pathway Regulation Of Timing Of Cell Differentiation Embryonic Digestive Tract Development Embryonic Skeletal System Development Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cell Division Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Cardiac Muscle Cell Proliferation Lung-associated Mesenchyme Development Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Vascular Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Vascular Smooth Muscle Cell Differentiation Involved In Phenotypic Switching
Pathways		PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR1 Signaling by activated point mutants of FGFR3 FGFR4 ligand binding and activation FGFR3b ligand binding and activation FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation FGFR3 mutant receptor activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR1 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by FGFR3 point mutants in cancer
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Asthma (childhood onset) ( 27611488) Central corneal thickness ( 29760442) Chin dimples ( 27182965) Corneal structure ( 23291589) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Modified Stumvoll Insulin Sensitivity Index (BMI interaction) ( 27416945) Systolic blood pressure ( 30224653)
Interacting Genes		4 interacting genes: FGFR1 FGFR2 FGFR3 FGFR4
Entrez ID		2254
HPRD ID		02951
Ensembl ID		ENSG00000102678
Uniprot IDs		P31371
PDB IDs		1G82 1IHK 5W59
Enriched GO Terms of Interacting Partners?
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