MECOM

Description		MDS1 and EVI1 complex locus
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GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytosol Nuclear Speck
	Molecular Function	DNA Binding DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding Histone Methyltransferase Activity (H3-K9 Specific)
	Biological Process	Apoptotic Process Regulation Of Gene Expression Hemopoiesis Cell Differentiation Negative Regulation Of Programmed Cell Death Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Histone H3-K9 Methylation Regulation Of Cell Cycle Heterochromatin Organization Hematopoietic Stem Cell Proliferation
Pathways		PKMTs methylate histone lysines Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases		Chronic myeloid leukemia (CML)
GWAS		Aging (time to event) ( 21782286) Blood pressure ( 21909110) Blood pressure (smoking interaction) ( 25189868) Blood urea nitrogen levels ( 31152163 29403010) Bone mineral density (lumbar spine) in inflammatory bowel disease ( 29603369) Childhood and early adolescence aggressive behavior ( 26087016) Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure ( 27841878 21909115 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Estimated glomerular filtration rate ( 31152163 31015462) FEV1 ( 30804560) Glaucoma ( 30054594) Glomerular filtration rate ( 29403010) Height ( 31562340) Hematocrit ( 27863252) Hematology traits ( 30576415) Intraocular pressure ( 29617998 29785010 31959993 30054594) Joint damage in rheumatoid arthritis ( 31596875) Late-onset Alzheimer's disease ( 27770636) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 30804560) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antiglaucoma preparations and miotics) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Myeloproliferative neoplasms ( 25849990) Nasopharyngeal carcinoma ( 26545403) Osteoporosis ( 23349225) Phoneme awareness ( 30741946) Platelet count ( 27863252) Plateletcrit ( 27863252) Prostate cancer ( 29892016) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Red blood cell count ( 27863252) Renal function-related traits (BUN) ( 22797727) Response to fenofibrate (triglyceride levels) ( 27002377) Systolic blood pressure ( 27841878 21909115 28739976 27618447 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Total intracranial volume ( 31530798) Urate levels ( 31578528)
Interacting Genes		15 interacting genes: CREBBP CTBP1 CTBP2 HDAC1 HDAC4 HIC1 KAT2B MBD3 PIK3R3 PRMT1 SMAD1 SMAD2 SMAD3 SMAD4 UBE2I
Entrez ID		2122
HPRD ID		01310
Ensembl ID		ENSG00000085276
Uniprot IDs		A0A0C3SFZ7 C7FEN9 Q03112
PDB IDs		6BW3
Enriched GO Terms of Interacting Partners?
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