S1PR1

Description		sphingosine-1-phosphate receptor 1
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GO Annotations	Cellular Component	Cell Nucleoplasm Endosome Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Intrinsic Component Of Plasma Membrane Intracellular Membrane-bounded Organelle Membrane Raft
	Molecular Function	G Protein-coupled Receptor Binding G Protein-coupled Receptor Activity Protein Binding Sphingosine-1-phosphate Receptor Activity Sphingolipid Binding
	Biological Process	Angiogenesis Blood Vessel Maturation Cardiac Muscle Tissue Growth Involved In Heart Morphogenesis Sphingosine-1-phosphate Receptor Signaling Pathway Chemotaxis Cell Adhesion G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Brain Development Cell Migration Cytokine-mediated Signaling Pathway Transmission Of Nerve Impulse Lamellipodium Assembly Regulation Of Cell Adhesion Neuron Differentiation Positive Regulation Of Cell Migration Regulation Of Bone Mineralization Leukocyte Chemotaxis Actin Cytoskeleton Reorganization Positive Regulation Of GTPase Activity Regulation Of Bone Resorption Endothelial Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Positive Chemotaxis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Negative Regulation Of Stress Fiber Assembly Heart Trabecula Morphogenesis T Cell Migration
Pathways		G alpha (i) signalling events Lysosphingolipid and LPA receptors Interleukin-4 and Interleukin-13 signaling
Drugs		Asfotase Alfa
Diseases
GWAS		Irritable bowel syndrome ( 29673008) Lymphocyte counts ( 29403010 27863252) Multiple sclerosis and C-reactive protein levels (pleiotropy) ( 26920376) Multiple sclerosis and HDL levels (pleiotropy) ( 26920376) Sensorimotor dexterity ( 31596458)
Interacting Genes		9 interacting genes: AKT1 APP CAV1 CMSS1 GNAI1 GNAI3 HTR1A HTR1D PDGFRB
Entrez ID		1901
HPRD ID		03578
Ensembl ID		ENSG00000170989
Uniprot IDs		P21453
PDB IDs		3V2W 3V2Y
Enriched GO Terms of Interacting Partners?
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