CYP27A1

Description		cytochrome P450 family 27 subfamily A member 1
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix
	Molecular Function	Iron Ion Binding Steroid Hydroxylase Activity Heme Binding Vitamin D3 25-hydroxylase Activity Cholesterol 26-hydroxylase Activity Cholestanetriol 26-monooxygenase Activity
	Biological Process	Bile Acid Biosynthetic Process Cholesterol Catabolic Process Sterol Metabolic Process Calcitriol Biosynthetic Process From Calciol Oxidation-reduction Process
Pathways		Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol Endogenous sterols Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
Drugs
Diseases		Cerebrotendinous xanthomatosis; Van Bogaert-Scherer-Epstein Disease
GWAS		Diastolic blood pressure ( 30224653) High light scatter reticulocyte count ( 27863252) Male-pattern baldness ( 28196072) Reticulocyte count ( 27863252)
Interacting Genes		2 interacting genes: MTDH PRDX4
Entrez ID		1593
HPRD ID		05939
Ensembl ID		ENSG00000135929
Uniprot IDs		Q02318
PDB IDs		1MFX
Enriched GO Terms of Interacting Partners?
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