PRICKLE1

Description		prickle planar cell polarity protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Nuclear Membrane
	Molecular Function	Protein Binding Zinc Ion Binding
	Biological Process	Neural Tube Closure Protein Import Into Nucleus Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Aorta Development Negative Regulation Of Transcription, DNA-templated Wnt Signaling Pathway, Planar Cell Polarity Pathway Coronary Vasculature Development Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation
Pathways		Asymmetric localization of PCP proteins
Drugs
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Blood urea nitrogen levels ( 31152163) Colorectal cancer ( 30529582) Endometrial cancer (Non-endometrioid histology) ( 30093612) Graves' disease ( 22922229) Heart failure ( 20445134) Hip circumference adjusted for BMI ( 28552196) Impulsivity (non-planning) ( 30718321) Inferior parietal cortex volume ( 31530798) Multiple sclerosis ( 31604244) Night sleep phenotypes ( 27126917) Parkinson's disease ( 27182965) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		5 interacting genes: ANO6 PRPF31 SMURF2 UTP14C VIP
Entrez ID		144165
HPRD ID		16341
Ensembl ID		ENSG00000139174
Uniprot IDs		A0A024R0W7 B3KVG3 B3KVG6 Q96MT3
PDB IDs
Enriched GO Terms of Interacting Partners?
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