ADAMTS13

Description		ADAM metallopeptidase with thrombospondin type 1 motif 13
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GO Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum Lumen Cell Surface Extracellular Matrix
	Molecular Function	Metalloendopeptidase Activity Integrin Binding Calcium Ion Binding Protein Binding Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Proteolysis Cell-matrix Adhesion Integrin-mediated Signaling Pathway Glycoprotein Metabolic Process Response To Toxic Substance Response To Amine Protein Processing Platelet Activation Response To Potassium Ion Peptide Catabolic Process Cellular Response To Lipopolysaccharide Cellular Response To Interferon-gamma Cellular Response To Interleukin-4 Cellular Response To Tumor Necrosis Factor
Pathways		Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs
Diseases		Thrombotic thrombocytopenic purpura; Moschcowitz disease; Schulman-Upshaw syndrome
GWAS		Activated partial thromboplastin time ( 22703881) ADAMTS13 activity ( 25934476) ADAMTS13 levels ( 29296746) Blood protein levels ( 30072576 29875488 28240269) Circulating fibroblast growth factor 23 levels ( 30217807) Coagulation factor levels ( 23267103) Cobalt levels ( 26025379) Gut microbiota (functional units) ( 27694959) Liver enzyme levels ( 18940312) Pancreatic cancer ( 25086665) vWF levels in ischaemic stroke and hyperhomocysteinaemia ( 28495826)
Interacting Genes		2 interacting genes: EXOSC2 VWF
Entrez ID		11093
HPRD ID		04994
Ensembl ID		ENSG00000160323
Uniprot IDs		Q76LX8
PDB IDs		3GHM 3GHN 3VN4 6QIG
Enriched GO Terms of Interacting Partners?
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