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COPS8

Description COP9 signalosome subunit 8
Image
GO Annotations Cellular Component
  • Nucleus
  • Nucleoplasm
  • Cytosol
  • COP9 Signalosome
  • Perinuclear Region Of Cytoplasm
  • Extracellular Exosome
Molecular Function
  • Protein Binding
Biological Process
  • Protein Deneddylation
  • Nucleotide-excision Repair, DNA Damage Recognition
  • Transcription-coupled Nucleotide-excision Repair
  • Protein Phosphorylation
  • Activation Of NF-kappaB-inducing Kinase Activity
  • Negative Regulation Of Cell Proliferation
  • COP9 Signalosome Assembly
  • Post-translational Protein Modification
Pathways
  • DNA Damage Recognition in GG-NER
  • Formation of TC-NER Pre-Incision Complex
  • Cargo recognition for clathrin-mediated endocytosis
  • Neddylation
Drugs
Diseases
GWAS
  • Asthma ( 27611488)
  • Body mass index ( 25673413)
  • Lung cancer ( 28604730)
  • Motion sickness ( 25628336)
  • Pulse pressure ( 27841878)
  • Systemic lupus erythematosus ( 19838195)
Interacting Genes 16 interacting genes: COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A CUL1 CUL5 DDB1 EIF3E GPS1 ITPK1 MAPRE1 NFKBIA TP53 USHBP1
Entrez ID 10920
HPRD ID 16737
Ensembl ID ENSG00000198612
Uniprot IDs A0A024R4D1 Q99627
PDB IDs 4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2025

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