PDE10A

Description		phosphodiesterase 10A
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GO Annotations	Cellular Component	Cytosol Membrane Perikaryon
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity CGMP-stimulated Cyclic-nucleotide Phosphodiesterase Activity CAMP Binding CGMP Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	CAMP Catabolic Process G Protein-coupled Receptor Signaling Pathway Regulation Of Protein Kinase A Signaling Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of CAMP-mediated Signaling CGMP Catabolic Process
Pathways		cGMP effects G alpha (s) signalling events
Drugs		Caffeine Dipyridamole Papaverine 4,5-bis(4-methoxyphenyl)-2-thiophen-2-yl-1H-imidazole 2-({4-[4-(pyridin-4-ylmethyl)-1H-pyrazol-3-yl]phenoxy}methyl)quinoline 2-{[4-(4-pyridin-4-yl-1H-pyrazol-3-yl)phenoxy]methyl}quinoline 2-{[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)phenoxy]methyl}quinoline 6,7-DIMETHOXY-4-[(3R)-3-(2-NAPHTHYLOXY)PYRROLIDIN-1-YL]QUINAZOLINE 6,7-DIMETHOXY-4-[(3R)-3-(QUINOXALIN-2-YLOXY)PYRROLIDIN-1-YL]QUINAZOLINE Tofisopam Triflusal Trapidil
Diseases
GWAS		Age-related nuclear cataracts ( 24951543) Birth weight ( 31043758) Body mass index ( 28552196) Chronotype ( 30696823) Conduct disorder (symptom count) ( 20585324) Cortisol levels (saliva) ( 28843169) Diastolic blood pressure ( 28135244 27841878) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Height ( 28552196) Hyperthyroidism ( 30367059) Hypothyroidism ( 30367059 27182965) Inhibitory control ( 29251981) Medication use (thyroid preparations) ( 31015401) Metabolite levels ( 23823483) Parkinson's disease ( 26227905) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Plasma thyroid-stimulating hormone levels ( 28333968) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Systolic blood pressure ( 27841878) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 25743335)
Interacting Genes		3 interacting genes: CASP3 TOP1 WDR3
Entrez ID		10846
HPRD ID		17828
Ensembl ID		ENSG00000112541
Uniprot IDs		A0A1B1UZQ1 A0A1B1UZR0 Q9Y233
PDB IDs		1LRB 2OUN 2OUP 2OUQ 2OUR 2OUS 2OUU 2OUV 2OUY 2WEY 2Y0J 2ZMF 3SN7 3SNI 3SNL 3UI7 3UUO 3WI2 3WS8 3WS9 3WYK 3WYL 3WYM 4AEL 4AJD 4AJF 4AJG 4AJM 4BBX 4DDL 4DFF 4FCB 4FCD 4HEU 4HF4 4LKQ 4LLJ 4LLK 4LLP 4LLX 4LM0 4LM1 4LM2 4LM3 4LM4 4MRW 4MRZ 4MS0 4MSA 4MSC 4MSE 4MSH 4MSN 4MUW 4MVH 4P0N 4P1R 4PHW 4TPM 4TPP 4WN1 4XY2 4YQH 4YS7 4ZO5 5AXP 5AXQ 5B4K 5B4L 5C1W 5C28 5C29 5C2A 5C2E 5C2H 5DH4 5DH5 5EDE 5EDG 5EDH 5EDI 5I2R 5K9R 5UWF 5XUI 5XUJ 5ZNL 6IJH 6IJI 6KDX 6KDZ 6KE0 6MSA 6MSC
Enriched GO Terms of Interacting Partners?
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