MED12 and NANOG

Number of citations: 0 (PubMedID 19036726)
Data Source: BioGRID (two hybrid, affinity chromatography technology)

		MED12	NANOG
Name		mediator complex subunit 12	Nanog homeobox
Structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Membrane Mediator Complex CKM Complex	Chromatin Nucleus Nucleoplasm Nucleolus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Beta-catenin Binding Nuclear Vitamin D Receptor Binding Nuclear Thyroid Hormone Receptor Binding Ubiquitin Protein Ligase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Somitogenesis Neural Tube Closure Regulation Of Transcription By RNA Polymerase II Endoderm Development Heart Development Oligodendrocyte Development Schwann Cell Development Protein Ubiquitination Spinal Cord Development Neural Tube Development Somatic Stem Cell Population Maintenance Post-anal Tail Morphogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Embryonic Neurocranium Morphogenesis Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Transcription Initiation By RNA Polymerase II Axis Elongation Involved In Somitogenesis Embryonic Brain Development	Negative Regulation Of Transcription By RNA Polymerase II Endodermal Cell Fate Specification Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Stem Cell Population Maintenance Cell Differentiation Somatic Stem Cell Population Maintenance Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Stem Cell Proliferation
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation of pluripotent stem cells Interleukin-4 and Interleukin-13 signaling Germ layer formation at gastrulation Formation of the anterior neural plate Specification of primordial germ cells
Diseases		MED12-related disorders, including: Lujan-Fryns syndrome (LFS); Lujan syndrome; X-linked mental retardation with Marfanoid habitus; FG syndrome type 1 (FGS1); Opitz-Kaveggia syndrome FG syndrome (FGS); Opitz-Kaveggia syndrome	None
GWAS		High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Immature fraction of reticulocytes ( 32888494 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Uterine fibroids ( 31649266 )	No GWAS studies recorded
Interacting Genes		15 interacting genes: CDK8 CEBPA ESR1 ESR2 GLI3 LYST MED1 MED13 MED26 MED8 MED9 NANOG PPARGC1A SOX9 SREBF1	8 interacting genes: BRAF MED12 PRKCE RBPMS RHOXF2 SPOP TRRAP USP21
Entrez ID		9968	79923
HPRD ID		02176	06397
Ensembl ID		ENSG00000184634	ENSG00000111704
Uniprot IDs		Q93074	A8K4D1 Q9H9S0
PDB IDs		8TQ2 8TQC 8TQW	2KT0 4RBO
GO Terms Enriched among Interactors		Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Mediator Complex Regulation Of DNA-templated Transcription Initiation RNA Polymerase II Preinitiation Complex Assembly Regulation Of Transcription By RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Biosynthetic Process Protein-DNA Complex Assembly Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Coregulator Activity Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Core Mediator Complex Nucleoplasm Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of RNA Metabolic Process Chromatin Positive Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Primary Metabolic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of Stem Cell Proliferation DNA-binding Transcription Factor Activity Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Macromolecule Metabolic Process DNA-templated Transcription Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Elongation Chromatin Binding Nuclear Estrogen Receptor Activity Mammary Gland Branching Involved In Pregnancy DNA Binding	Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Fibroblast Migration Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Coactivator Activity Protein Modification Process Positive Regulation Of Biosynthetic Process Nucleus Somatic Stem Cell Population Maintenance Positive Regulation Of Macromolecule Metabolic Process Ethanol Binding Axis Elongation Involved In Somitogenesis Maintenance Of Cell Number Stem Cell Population Maintenance Positive Regulation Of Cell-substrate Adhesion TRAM-dependent Toll-like Receptor 4 Signaling Pathway Transcription Coregulator Activity