MAFB and FOSL1

Number of citations: 48 (PubMedID 23661758)
Data Source: BioGRID (fluorescent resonance energy transfer)

		MAFB	FOSL1
Name		MAF bZIP transcription factor B	FOS like 1, AP-1 transcription factor subunit
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Protein-containing Complex Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Segment Specification Sensory Organ Development Response To Nutrient Respiratory Gaseous Exchange By Respiratory System Gene Expression Protein Processing Rhombomere 5 Development Rhombomere 6 Development Abducens Nerve Formation Keratinocyte Differentiation T Cell Differentiation In Thymus Brain Segmentation Inner Ear Morphogenesis Fat Cell Differentiation Regulation Of Myeloid Cell Differentiation Negative Regulation Of Erythrocyte Differentiation Negative Regulation Of Osteoclast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Thymus Development Integrated Stress Response Signaling Cornified Envelope Assembly	In Utero Embryonic Development Toll-like Receptor Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Chemotaxis Inflammatory Response Cellular Defense Response Vitellogenesis Positive Regulation Of Cell Population Proliferation Response To Wounding Response To Virus Gene Expression Cytokine-mediated Signaling Pathway Placenta Blood Vessel Development Integrated Stress Response Signaling Positive Regulation Of MiRNA Transcription Positive Regulation Of DNA-templated Transcription Initiation
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis	NGF-stimulated transcription NGF-stimulated transcription
GWAS		Adult body size ( 32376654 ) Apolipoprotein B levels ( 32203549 ) Aspartate aminotransferase levels ( 33547301 ) Birth weight ( 31043758 27680694 ) Bone mineral density (hip) ( 30172743 ) Cholesterol, total ( 20686565 24097068 25961943 ) Cognitive decline rate in late mild cognitive impairment ( 26252872 ) Drug-induced Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN) ( 21221126 ) Dupuytren's disease ( 21732829 28886342 ) Height ( 25282103 ) Iron status biomarkers (ferritin levels) ( 33536631 ) LDL cholesterol ( 25961943 24097068 20686565 19060906 ) LDL cholesterol levels ( 28334899 32203549 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Low density lipoprotein cholesterol levels ( 33339817 ) Nonsyndromic cleft lip ( 31609978 ) Nonsyndromic cleft lip with cleft palate ( 28232668 ) Nonsyndromic cleft lip with or without cleft palate ( 25775280 ) Obesity-related traits ( 23251661 ) Paneth cell defects in Crohn's disease ( 28352666 ) Plasma parathyroid hormone levels ( 30134803 ) QT interval (ambient particulate matter interaction) ( 28749367 ) Red blood cell count ( 32888494 ) Response to TNF antagonist treatment ( 18615156 ) Serum alkaline phosphatase levels ( 33547301 ) Serum total protein levels ( 29403010 ) Spleen volume ( 34128465 ) Total body bone mineral density ( 29304378 ) Total cholesterol levels ( 33339817 ) Triglyceride levels ( 32203549 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	Acne (severe) ( 24927181 ) Asthma ( 31959851 ) Eosinophil count ( 27863252 32888494 ) Eosinophil percentage of white cells ( 27863252 32888494 ) Hip circumference adjusted for BMI ( 34021172 ) Inflammatory bowel disease ( 23128233 ) Psoriasis ( 28537254 ) Sum eosinophil basophil counts ( 27863252 )
Interacting Genes		11 interacting genes: ATF4 BACH1 FOS FOSL1 HOXD12 JUN KRTAP4-2 MAF ZDHHC2 ZFP64 ZWINT	30 interacting genes: ABL1 ATF3 ATF4 ATXN1 BATF3 CALCOCO1 CCDC120 CEBPA CEBPE CEBPG CREB5 DDIT3 DNMT3L EP300 ERCC6 GCC1 JUN JUNB KIFC3 KPNA1 LDOC1 MAF MAFB NME7 PARVG PIN1 TAB2 TRIM24 USF1 WFDC1
Entrez ID		9935	8061
HPRD ID		07129	00643
Ensembl ID		ENSG00000204103	ENSG00000175592
Uniprot IDs		Q9Y5Q3	A0A0S2Z595 E9PKL5 E9PPX2 P15407
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Integrated Stress Response Signaling RNA Polymerase II Transcription Regulator Complex Sequence-specific Double-stranded DNA Binding Chromatin DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of MiRNA Transcription Transcription Factor AP-1 Complex Positive Regulation Of MiRNA Metabolic Process Promoter-specific Chromatin Binding DNA Binding Transcription Regulator Complex Regulation Of MiRNA Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding General Transcription Initiation Factor Binding Regulation Of MiRNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Embryonic Hemopoiesis Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process SMAD Protein Signal Transduction Response To Muscle Stretch R-SMAD Binding Intracellular Signaling Cassette Cellular Response To Metal Ion Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Stress Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Identical Protein Binding Myeloid Cell Differentiation Transcription Cis-regulatory Region Binding Medium-term Memory Cellular Response To Prolactin Positive Regulation Of Hepatocyte Apoptotic Process Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process	Integrated Stress Response Signaling RNA Polymerase II Transcription Regulator Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Intracellular Signaling Cassette Positive Regulation Of Transcription By RNA Polymerase II Chromatin Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Intracellular Signal Transduction Positive Regulation Of Metabolic Process DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Regulation Of RNA Metabolic Process Myeloid Cell Differentiation Leukocyte Differentiation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cellular Response To Stress Regulation Of Primary Metabolic Process DNA-templated Transcription Positive Regulation Of Gene Expression Mononuclear Cell Differentiation Sequence-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Animal Organ Development Regulation Of Gene Expression Signal Transduction Identical Protein Binding Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Response To Stress Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Response To Nutrient Levels Negative Regulation Of Macromolecule Metabolic Process Nucleobase-containing Compound Biosynthetic Process Developmental Process