MAFB and ZDHHC2

Number of citations: 41 (PubMedID 20211142)
Data Source: BioGRID (two hybrid)

		MAFB	ZDHHC2
Name		MAF bZIP transcription factor B	zDHHC palmitoyltransferase 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex RNA Polymerase II Transcription Regulator Complex	Golgi Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Postsynaptic Density Membrane Synapse Recycling Endosome Membrane Postsynaptic Recycling Endosome Postsynaptic Recycling Endosome Membrane Glutamatergic Synapse
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Protein-containing Complex Binding Sequence-specific Double-stranded DNA Binding	Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity Protein Homodimerization Activity Protein-cysteine S-stearoyltransferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Segment Specification Sensory Organ Development Response To Nutrient Respiratory Gaseous Exchange By Respiratory System Gene Expression Protein Processing Rhombomere 5 Development Rhombomere 6 Development Abducens Nerve Formation Keratinocyte Differentiation T Cell Differentiation In Thymus Brain Segmentation Inner Ear Morphogenesis Fat Cell Differentiation Regulation Of Myeloid Cell Differentiation Negative Regulation Of Erythrocyte Differentiation Negative Regulation Of Osteoclast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Thymus Development Integrated Stress Response Signaling Cornified Envelope Assembly	Protein Targeting To Membrane Synapse Assembly Synaptic Vesicle Maturation Peptidyl-L-cysteine S-palmitoylation Regulation Of Cell-cell Adhesion Regulation Of Protein Catabolic Process Regulation Of Neuronal Synaptic Plasticity Protein Localization To Plasma Membrane Regulation Of Postsynaptic Neurotransmitter Receptor Diffusion Trapping Positive Regulation Of Long-term Synaptic Potentiation Protein Localization To Membrane Raft Regulation Of Protein Localization To Plasma Membrane Protein Localization To Postsynaptic Membrane Positive Regulation Of AMPA Glutamate Receptor Clustering Positive Regulation Of Endosome To Plasma Membrane Protein Transport
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis	Surfactant metabolism Maturation of spike protein
GWAS		Adult body size ( 32376654 ) Apolipoprotein B levels ( 32203549 ) Aspartate aminotransferase levels ( 33547301 ) Birth weight ( 31043758 27680694 ) Bone mineral density (hip) ( 30172743 ) Cholesterol, total ( 20686565 24097068 25961943 ) Cognitive decline rate in late mild cognitive impairment ( 26252872 ) Drug-induced Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN) ( 21221126 ) Dupuytren's disease ( 21732829 28886342 ) Height ( 25282103 ) Iron status biomarkers (ferritin levels) ( 33536631 ) LDL cholesterol ( 25961943 24097068 20686565 19060906 ) LDL cholesterol levels ( 28334899 32203549 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Low density lipoprotein cholesterol levels ( 33339817 ) Nonsyndromic cleft lip ( 31609978 ) Nonsyndromic cleft lip with cleft palate ( 28232668 ) Nonsyndromic cleft lip with or without cleft palate ( 25775280 ) Obesity-related traits ( 23251661 ) Paneth cell defects in Crohn's disease ( 28352666 ) Plasma parathyroid hormone levels ( 30134803 ) QT interval (ambient particulate matter interaction) ( 28749367 ) Red blood cell count ( 32888494 ) Response to TNF antagonist treatment ( 18615156 ) Serum alkaline phosphatase levels ( 33547301 ) Serum total protein levels ( 29403010 ) Spleen volume ( 34128465 ) Total body bone mineral density ( 29304378 ) Total cholesterol levels ( 33339817 ) Triglyceride levels ( 32203549 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	Diastolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415 ) Parkinson's disease ( 32201043 ) Schizophrenia ( 28991256 30285260 ) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415 )
Interacting Genes		11 interacting genes: ATF4 BACH1 FOS FOSL1 HOXD12 JUN KRTAP4-2 MAF ZDHHC2 ZFP64 ZWINT	2 interacting genes: MAFB MSX2
Entrez ID		9935	51201
HPRD ID		07129	15715
Ensembl ID		ENSG00000204103	ENSG00000104219
Uniprot IDs		Q9Y5Q3	A0A140VKD9 Q9UIJ5
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Integrated Stress Response Signaling RNA Polymerase II Transcription Regulator Complex Sequence-specific Double-stranded DNA Binding Chromatin DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of MiRNA Transcription Transcription Factor AP-1 Complex Positive Regulation Of MiRNA Metabolic Process Promoter-specific Chromatin Binding DNA Binding Transcription Regulator Complex Regulation Of MiRNA Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding General Transcription Initiation Factor Binding Regulation Of MiRNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Embryonic Hemopoiesis Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process SMAD Protein Signal Transduction Response To Muscle Stretch R-SMAD Binding Intracellular Signaling Cassette Cellular Response To Metal Ion Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Stress Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Identical Protein Binding Myeloid Cell Differentiation Transcription Cis-regulatory Region Binding Medium-term Memory Cellular Response To Prolactin Positive Regulation Of Hepatocyte Apoptotic Process Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process	Transcription Regulator Complex Pattern Specification Process Positive Regulation Of Timing Of Catagen Embryonic Nail Plate Morphogenesis Cell Surface Receptor Signaling Pathway Involved In Heart Development Embryonic Morphogenesis Regulation Of Timing Of Catagen Activation Of Meiosis Positive Regulation Of Mesenchymal Cell Apoptotic Process Frontal Suture Morphogenesis Regionalization Brain Segmentation Abducens Nerve Formation Rhombomere 5 Development Rhombomere 6 Development Sequence-specific DNA Binding Cornified Envelope Assembly Cranial Suture Morphogenesis Sequence-specific Double-stranded DNA Binding Enamel Mineralization Endochondral Bone Growth Negative Regulation Of Keratinocyte Differentiation Bone Trabecula Formation Negative Regulation Of Erythrocyte Differentiation Rhombomere Development Mammary Gland Epithelium Development Positive Regulation Of Hair Follicle Development Mesenchymal Cell Apoptotic Process Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Negative Regulation Of Cell Differentiation Negative Regulation Of Epidermal Cell Differentiation Cardiac Conduction System Development Positive Regulation Of Meiotic Nuclear Division Wound Healing, Spreading Of Epidermal Cells Osteoblast Development Segment Specification Craniofacial Suture Morphogenesis Bone Growth Tooth Mineralization Branching Involved In Mammary Gland Duct Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Regulation Of Hair Follicle Development Chondrocyte Development Positive Regulation Of Meiotic Cell Cycle Negative Regulation Of Developmental Process Outflow Tract Septum Morphogenesis Regulation Of Hair Cycle Negative Regulation Of Transcription By RNA Polymerase II Embryonic Hindlimb Morphogenesis Cardiac Epithelial To Mesenchymal Transition