PAN2 and TNRC6A

Number of citations: 0 (PubMedID 21984185)
Data Source: BioGRID (pull down)

		PAN2	TNRC6A
Name		poly(A) specific ribonuclease subunit PAN2	trinucleotide repeat containing adaptor 6A
Structure		No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol PAN Complex	P-body Nucleoplasm Cytoplasm Golgi Apparatus Cytosol RISC Complex
	Molecular Function	3'-5'-RNA Exonuclease Activity Nucleic Acid Binding Nuclease Activity Exonuclease Activity Poly(A)-specific Ribonuclease Activity Cysteine-type Deubiquitinase Activity Protein Binding Hydrolase Activity Metal Ion Binding	Nucleic Acid Binding RNA Binding Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Processing Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly	Regulation Of Translation Endoderm Development Cellular Response To Starvation Regulatory NcRNA-mediated Gene Silencing P-body Assembly MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening
Pathways		Deadenylation of mRNA	Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway Post-transcriptional silencing by small RNAs Transcriptional regulation by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH1 mRNA translation by microRNAs Regulation of NPAS4 mRNA translation Regulation of MITF-M-dependent genes involved in apoptosis TGFBR3 expression Regulation of PD-L1(CD274) translation
GWAS		Axial length ( 24144296 ) Height ( 25429064 34054925 34270706 ) Refractive error ( 32231278 )	Adult body size ( 32376654 ) Age at first sexual intercourse ( 34211149 ) Alcohol consumption ( 31358974 ) Alcohol consumption (drinks per week) ( 30679032 30643258 ) Body size at age 10 ( 32376654 ) Brain morphology (MOSTest) ( 32665545 ) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143 ) Experiencing mood swings ( 29500382 ) General cognitive ability ( 29844566 ) Household income (MTAG) ( 31844048 ) Intelligence (MTAG) ( 29326435 ) Macular thickness ( 30535121 ) Mean platelet volume ( 32888494 ) Metabolic syndrome ( 31589552 ) Problematic alcohol use ( 32451486 ) Pulse pressure ( 30578418 27618448 27841878 ) Smoking initiation ( 33082346 ) Systolic blood pressure ( 27841878 27618448 30578418 ) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		9 interacting genes: ATM DYNLL1 PABPC1 PAN3 RBBP8 RBCK1 RNF144B TNRC6A TRIM35	10 interacting genes: DMRTB1 PAN2 QKI RBFOX2 SMARCB1 TRIM65 TRIP13 TXNL4A UBC WNK1
Entrez ID		9924	27327
HPRD ID		15640	11640
Ensembl ID		ENSG00000135473	ENSG00000090905
Uniprot IDs		Q504Q3	Q8NDV7
PDB IDs		Not available	5W6V 7RUP
GO Terms Enriched among Interactors		DNA Strand Resection Involved In Replication Fork Processing Site Of Double-strand Break Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of MRNA Catabolic Process Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Catabolic Process Positive Regulation Of MRNA Metabolic Process Poly(A) Binding DNA Double-strand Break Processing Macromolecule Catabolic Process Positive Regulation Of Catabolic Process RNA Catabolic Process Protein Ubiquitination Homologous Recombination Negative Regulation Of Mitotic Cell Cycle Protein Modification By Small Protein Conjugation Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Mitotic G2/M Transition Checkpoint Nucleobase-containing Compound Catabolic Process Negative Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Post-translational Protein Modification Negative Regulation Of Cell Cycle Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Ubiquitin Protein Ligase Activity Regulation Of MRNA Metabolic Process Apoptotic Process Establishment Of RNA Localization To Telomere Negative Regulation Of Metabolic Process Establishment Of Protein-containing Complex Localization To Telomere Programmed Cell Death Positive Regulation Of Telomerase Catalytic Core Complex Assembly Cell Death Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing PAN Complex Positive Regulation Of Organelle Assembly Positive Regulation Of RNA Metabolic Process P-body Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA-dependent Protein Kinase Activity Histone H2AXS139 Kinase Activity Catabolic Process Deoxyribonuclease Inhibitor Activity Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Gene Expression Response To Stress	RNA Metabolic Process Macromolecule Metabolic Process MRNA Processing