PAN2 and PAN3

Number of citations: 0 (PubMedID 14583602)
Data Source: HPRD (in vitro, in vivo)

		PAN2	PAN3
Name		poly(A) specific ribonuclease subunit PAN2	poly(A) specific ribonuclease subunit PAN3
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol PAN Complex	P-body Nucleus Cytoplasm Cytosol PAN Complex
	Molecular Function	3'-5'-RNA Exonuclease Activity Nucleic Acid Binding Nuclease Activity Exonuclease Activity Poly(A)-specific Ribonuclease Activity Cysteine-type Deubiquitinase Activity Protein Binding Hydrolase Activity Metal Ion Binding	Nucleotide Binding RNA Binding Poly(A)-specific Ribonuclease Activity Protein Kinase Activity Protein Binding ATP Binding Poly(A) Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Processing Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA MRNA Processing Protein Targeting Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly
Pathways		Deadenylation of mRNA	Deadenylation of mRNA
GWAS		Axial length ( 24144296 ) Height ( 25429064 34054925 34270706 ) Refractive error ( 32231278 )	Bipolar disorder ( 20351715 ) Body mass index ( 26426971 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Hepcidin/transferrin saturation ratio ( 27846281 ) Mean corpuscular volume ( 32888494 ) Monocyte count ( 27863252 ) Monocyte percentage of white cells ( 27863252 ) Pancreatic cancer ( 25086665 )
Interacting Genes		9 interacting genes: ATM DYNLL1 PABPC1 PAN3 RBBP8 RBCK1 RNF144B TNRC6A TRIM35	5 interacting genes: PABPC1 PAN2 RNF10 SVIL TNRC6B
Entrez ID		9924	255967
HPRD ID		15640	17818
Ensembl ID		ENSG00000135473	ENSG00000152520
Uniprot IDs		Q504Q3	Q58A45
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		DNA Strand Resection Involved In Replication Fork Processing Site Of Double-strand Break Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of MRNA Catabolic Process Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Catabolic Process Positive Regulation Of MRNA Metabolic Process Poly(A) Binding DNA Double-strand Break Processing Macromolecule Catabolic Process Positive Regulation Of Catabolic Process RNA Catabolic Process Protein Ubiquitination Homologous Recombination Negative Regulation Of Mitotic Cell Cycle Protein Modification By Small Protein Conjugation Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Mitotic G2/M Transition Checkpoint Nucleobase-containing Compound Catabolic Process Negative Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Post-translational Protein Modification Negative Regulation Of Cell Cycle Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Ubiquitin Protein Ligase Activity Regulation Of MRNA Metabolic Process Apoptotic Process Establishment Of RNA Localization To Telomere Negative Regulation Of Metabolic Process Establishment Of Protein-containing Complex Localization To Telomere Programmed Cell Death Positive Regulation Of Telomerase Catalytic Core Complex Assembly Cell Death Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing PAN Complex Positive Regulation Of Organelle Assembly Positive Regulation Of RNA Metabolic Process P-body Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA-dependent Protein Kinase Activity Histone H2AXS139 Kinase Activity Catabolic Process Deoxyribonuclease Inhibitor Activity Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Gene Expression Response To Stress	Positive Regulation Of MRNA Catabolic Process Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of MRNA Metabolic Process Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of MRNA Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process P-body PAN Complex Mitochondrial Translational Initiation Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Positive Regulation Of Catabolic Process Nucleic Acid Binding Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Post-transcriptional Regulation Of Gene Expression MCRD-mediated MRNA Stability Complex Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Regulatory NcRNA-mediated Gene Silencing Microtubule Minus-end RNA Catabolic Process Negative Regulation Of Schwann Cell Proliferation Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Adenohypophysis Development CRD-mediated MRNA Stabilization Spinal Cord Association Neuron Differentiation Poly(A)-specific Ribonuclease Activity Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Actin Filament Severing Translation Activator Activity Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Hypothalamus Development