UBAP2L and ZP3

Number of citations: 29 (PubMedID 19945174)
Data Source: BioGRID (two hybrid)

		UBAP2L	ZP3
Name		ubiquitin associated protein 2 like	zona pellucida glycoprotein 3
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Chromosome Cytoplasm Cytoplasmic Stress Granule PcG Protein Complex	Extracellular Region Extracellular Space Plasma Membrane Membrane Extracellular Matrix Egg Coat
	Molecular Function	RNA Binding Protein Binding	Extracellular Matrix Structural Constituent Protein Binding Carbohydrate Binding Acrosin Binding Structural Constituent Of Egg Coat Identical Protein Binding Receptor Ligand Activity
	Biological Process	Binding Of Sperm To Zona Pellucida Stress Granule Assembly Hematopoietic Stem Cell Homeostasis Positive Regulation Of Stress Granule Assembly	Positive Regulation Of Type IV Hypersensitivity Blastocyst Formation Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Leukocyte Migration Positive Regulation Of Humoral Immune Response Signal Transduction Single Fertilization Binding Of Sperm To Zona Pellucida Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-4 Production Egg Coat Formation Positive Regulation Of T Cell Proliferation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Oocyte Development Positive Regulation Of Inflammatory Response Positive Regulation Of Acrosome Reaction Negative Regulation Of Binding Of Sperm To Zona Pellucida Positive Regulation Of Acrosomal Vesicle Exocytosis Positive Regulation Of Ovarian Follicle Development Positive Regulation Of Antral Ovarian Follicle Growth
Pathways		None	Interaction With Cumulus Cells And The Zona Pellucida
GWAS		Bipolar disorder ( 31043756 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (min-P) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Diastolic blood pressure ( 30224653 ) Fish- and plant-related diet ( 32066663 ) Smoking initiation ( 30617275 33082346 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 )	Parkinson disease and lewy body pathology ( 25663231 )
Interacting Genes		12 interacting genes: ATXN1 FXR1 G3BP1 ITCH LINC00624 MTNR1A MTNR1B NEDD4 PLXNA2 PRRC2A SUMO2 ZP3	11 interacting genes: ACR CLDN11 ENGASE FURIN MALL MICALL1 MRPS16 OR2L13 PCDH17 SPACA3 UBAP2L
Entrez ID		9898	7784
HPRD ID		06665	01690
Ensembl ID		ENSG00000143569	ENSG00000188372
Uniprot IDs		A0AA34QVE6 B4DYY5 F8W726 Q14157	P21754
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Melatonin Receptor Activity Cell Cortex	Acrosomal Matrix Sperm-egg Recognition Cell-cell Recognition Cell Recognition Binding Of Sperm To Zona Pellucida Acrosome Matrix Dispersal Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Mannosyl-glycoprotein Endo-beta-N-acetylglucosaminidase Activity Cytoplasmic Side Of Endosome Membrane Amidase Activity Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Slow Endocytic Recycling Axon Ensheathment Negative Regulation Of Receptor Catabolic Process Presynaptic Active Zone Assembly Protease Binding Acrosomal Vesicle Viral Translation Viral Life Cycle Serine-type Peptidase Activity Plasma Membrane Organization Cytokine Precursor Processing Nerve Growth Factor Binding Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Transforming Growth Factor Beta1 Production Regulation Of Synaptic Vesicle Clustering Serine-type Endopeptidase Activity Fucose Binding Positive Regulation Of Stress Granule Assembly Lysozyme Activity