SEPTIN7 and SEPTIN9

Number of citations: 106 (PubMedID 35271311)
Data Source: BioGRID (affinity chromatography technology, biochemical, cross-linking study), HPRD (in vivo, in vitro)

		SEPTIN7	SEPTIN9
Name		septin 7	septin 9
Structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Stress Fiber Nucleus Chromosome Cytoplasm Spindle Cytosol Cytoskeleton Cilium Axoneme Septin Ring Microtubule Cytoskeleton Apical Plasma Membrane Midbody Septin Complex Motile Cilium Cell Division Site Cleavage Furrow Cell Projection Extracellular Exosome Sperm Annulus Non-motile Cilium	Stress Fiber Cytoplasm Cytoskeleton Microtubule Cilium Axoneme Septin Ring Actin Cytoskeleton Microtubule Cytoskeleton Septin Complex Cell Division Site Intercellular Bridge Perinuclear Region Of Cytoplasm Non-motile Cilium
	Molecular Function	Nucleotide Binding GTPase Activity Structural Molecule Activity Protein Binding GTP Binding Identical Protein Binding Cadherin Binding Molecular Adaptor Activity	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Cadherin Binding Molecular Adaptor Activity
	Biological Process	Spermatogenesis Intracellular Protein Localization Regulation Of Embryonic Cell Shape Cell Differentiation Cell Division Cilium Assembly Cytoskeleton-dependent Cytokinesis Positive Regulation Of Non-motile Cilium Assembly	Intracellular Protein Localization Actin Cytoskeleton Organization Septin Cytoskeleton Organization Cell Division Cytoskeleton-dependent Cytokinesis Positive Regulation Of Non-motile Cilium Assembly
Pathways		MAPK6/MAPK4 signaling	None
Diseases		None	Hereditary neuralgic amyotrophy (HNA); Hereditary brachial plexus neuropathy
GWAS		No GWAS studies recorded	No GWAS studies recorded
Interacting Genes		15 interacting genes: ANLN CDC42EP2 CDC42EP3 CDC42EP5 CENPE GRIK1 HDAC6 LINC01554 OGT PCNT REL S100A4 SEPTIN11 SEPTIN5 SEPTIN9	21 interacting genes: APP CEBPA HIF1A HNRNPD HSF2BP IKBKG LINC00839 LINC01554 MYO1C MYO6 NEDD4 PIN1 PLK1 PTPRF RAB10 SEPTIN1 SEPTIN11 SEPTIN2 SEPTIN6 SEPTIN7 STK11
Entrez ID		989	10801
HPRD ID		04398	10360
Ensembl ID		ENSG00000122545	ENSG00000184640
Uniprot IDs		A0A023T695 A0A024RA87 A8K3D0 B4DNE4 G3V1Q4 Q16181	A0A0S2Z5A5 Q9UHD8
PDB IDs		2QAG 3T5D 3TW4 6N0B 6N12 6UQQ 7M6J 8SJJ	4YQF 5CYO 5CYP
GO Terms Enriched among Interactors		Microtubule Cytoskeleton Cytoskeleton Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Septin Ring Septin Complex Positive Regulation Of Pseudopodium Assembly Cell Division Site Positive Regulation Of Cell Projection Organization Cytoskeleton-dependent Cytokinesis Regulation Of Cell Projection Assembly Positive Regulation Of Cellular Component Biogenesis Septin Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Molecular Adaptor Activity Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein-containing Complex Assembly Rho Protein Signal Transduction Cell Division Regulation Of Cell Morphogenesis Positive Regulation Of Protein Polymerization Membraneless Organelle Assembly Regulation Of Actin Filament Polymerization Microtubule Regulation Of Cell Shape Positive Regulation Of Cellular Component Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Organelle Assembly Regulation Of Supramolecular Fiber Organization Regulation Of Organelle Organization Cytoplasm Positive Regulation Of Supramolecular Fiber Organization Regulation Of Cellular Component Organization Positive Regulation Of Cytoskeleton Organization Intracellular Signaling Cassette Microtubule Plus-end Directed Mitotic Chromosome Migration Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation Positive Regulation Of Organelle Organization Cytoskeletal Regulatory Protein Binding Septin Ring Assembly Regulation Of Cytoskeleton Organization Mitophagy Cytoskeleton Organization Regulation Of Cellular Component Size	Septin Ring Septin Complex Cell Division Site Cytoskeleton-dependent Cytokinesis Midbody Sperm Annulus Positive Regulation Of Catabolic Process Microtubule Cytoskeleton GTPase Activity Intracellular Protein Localization Molecular Adaptor Activity Positive Regulation Of Protein Metabolic Process GTP Binding Phosphothreonine Residue Binding Cellular Response To Stress Nucleotide Binding Cell Division Organelle Localization Phosphoserine Residue Binding Unconventional Myosin Complex Cytoskeletal Motor Activity Regulation Of Protein Metabolic Process Regulation Of Protein Localization To Nucleus Cleavage Furrow Response To Metal Ion Chromosome, Centromeric Region Kinetochore Cell Cortex Cell Projection Regulation Of Protein Localization Regulation Of Protein Catabolic Process Anoikis Positive Regulation Of Proteolysis Reproductive Process Positive Regulation Of Protein Catabolic Process Motile Cilium Intracellular Signal Transduction Protein Domain Specific Binding Stress Fiber Spindle Cellular Developmental Process Cytoplasm Cell Projection Organization Protein-containing Complex Spermatogenesis Male Gamete Generation Establishment Of Localization In Cell Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Establishment Of Organelle Localization DNA Damage Response