CEP170 and VAV2

Number of citations: 0 (PubMedID 18654987)
Data Source: BioGRID (two hybrid)

		CEP170	VAV2
Name		centrosomal protein 170	vav guanine nucleotide exchange factor 2
Structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Spindle Cytosol Cytoskeleton Microtubule Ciliary Basal Body Centriolar Subdistal Appendage	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Protein Binding	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Epidermal Growth Factor Receptor Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	None	Angiogenesis Immune Response-regulating Cell Surface Receptor Signaling Pathway Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Cell Size Response To Xenobiotic Stimulus Cell Migration Cell Projection Assembly Lamellipodium Assembly Platelet Activation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Xenobiotic Stimulus
Pathways		None	GPVI-mediated activation cascade GPVI-mediated activation cascade NRAGE signals death through JNK Regulation of actin dynamics for phagocytic cup formation DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization EPH-ephrin mediated repulsion of cells G alpha (12/13) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Signal transduction by L1 VEGFR2 mediated vascular permeability RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Azathioprine ADME
GWAS		Bronchopulmonary dysplasia ( 23897914 ) Chromium levels ( 26025379 ) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 ) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Estimated glomerular filtration rate ( 31015462 ) Lung cancer in ever smokers ( 28604730 ) Mental health study participation (completed survey) ( 31263887 ) Metabolite levels ( 23823483 ) Red cell distribution width ( 28957414 32888494 ) Schizophrenia ( 23974872 ) Smoking behaviour (cigarettes smoked per day) ( 31217584 ) Systemising ( 31508503 )	Central corneal thickness ( 29760442 ) Corneal astigmatism ( 30306274 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Hematocrit ( 27863252 ) Hemoglobin concentration ( 27863252 ) Hemoglobin levels ( 32327693 ) Multiple sclerosis ( 20598377 ) Pre-treatment viral load in HIV-1 infection ( 31219150 ) Red blood cell count ( 32888494 ) vWF and FVIII levels ( 21810271 )
Interacting Genes		8 interacting genes: CEBPA NDEL1 PPP1CA PTEN SNAPIN SRPK2 VAV2 YWHAG	67 interacting genes: AR ARIH1 BIRC6 BOD1L1 BRDT BZW1 CAV1 CBL CBLB CCNO CCT2 CCT3 CD19 CD44 CEP170 CHMP3 CRCP DCUN1D4 DNAJC21 EGFR EIF4G3 EPHB2 ERBB2 ERBB3 ERBB4 FNTA FUCA1 FYN GAB1 GAPVD1 GRB2 HNRNPF HSPH1 IPO4 MED21 MET MRGBP NCKAP5 NEK3 PHF10 PNMA1 POGZ PPM1B PRLR PRRG4 RAC1 RAD23A RBBP6 RHOA RHOG SERBP1 SF3A3 SH3BP2 SNW1 SOCS1 SRPK2 SRRT ST13 STK24 SYK TARBP2 TCP11 TOM1L1 TTN UBE4B USP38 VCPIP1
Entrez ID		9859	7410
HPRD ID		17172	02694
Ensembl ID		ENSG00000143702	ENSG00000160293
Uniprot IDs		Q5SW79	P52735
PDB IDs		4JON	2DLZ 2DM1 2LNW 2LNX 4ROJ 7RNV 7WFY
GO Terms Enriched among Interactors		Organelle Organization Developmental Maturation Intracellular Signaling Cassette Cellular Response To Xenobiotic Stimulus RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Developmental Process Presynapse Protein Stabilization Protein Dephosphorylation Phosphatase Activity Regulation Of Protein Stability RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Protein Serine/threonine Phosphatase Activity Cytosol Regulation Of Plasma Membrane Bounded Cell Projection Organization Negative Regulation Of Synaptic Vesicle Clustering Regulation Of Cell Projection Organization Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Central Nervous System Neuron Axonogenesis Cell Migration Cell Projection Organization Microtubule-based Process Regulation Of Cellular Component Size Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Size Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Vesicle Cytoskeletal Trafficking Retrograde Axonal Transport Positive Regulation Of Late Endosome To Lysosome Transport Vesicle Transport Along Microtubule Lysosome Localization Axon Cytoplasm Axonal Transport Axo-dendritic Transport Organelle Transport Along Microtubule Neurofilament Cytoskeleton Intracellular Signal Transduction Regulation Of Neuron Projection Development Lung Development Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Translational Initiation Negative Regulation Of Protein Phosphorylation Cell Motility Establishment Of Vesicle Localization CHOP-C/EBP Complex Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled	Protein Tyrosine Kinase Activity Protein Modification Process Peptidyl-tyrosine Phosphorylation Regulation Of Lymphocyte Activation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cytosol Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell Adhesion ERBB Signaling Pathway Protein Kinase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Lymphocyte Activation Regulation Of Cellular Localization Phosphotyrosine Residue Binding Protein Phosphorylation Positive Regulation Of Protein Localization To Membrane Regulation Of Cell Activation Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion ERBB2 Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Protein Modification Process Regulation Of Protein Localization Phosphorylation Protein Modification By Small Protein Conjugation Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Enzyme Binding Intracellular Signal Transduction Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Protein Ubiquitination Regulation Of Protein Localization To Membrane Kinase Activity Basal Plasma Membrane Positive Regulation Of Cell-cell Adhesion Protein Binding Regulation Of Protein Modification Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Positive Regulation Of T Cell Activation Positive Regulation Of Protein Localization Regulation Of Receptor Signaling Pathway Via JAK-STAT Macromolecule Metabolic Process