MAML1 and CDK8

Number of citations: 0 (PubMedID 15546612)
Data Source: BioGRID (pull down), HPRD (in vitro)

		MAML1	CDK8
Name		mastermind like transcriptional coactivator 1	cyclin dependent kinase 8
Structure
GO Annotations	Cellular Component	MAML1-RBP-Jkappa- ICN1 Complex Nucleus Nucleoplasm Nuclear Speck	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Nucleolus Mediator Complex Protein-containing Complex CKM Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding Protein Kinase Binding Peptide Antigen Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Atrioventricular Node Development Protein Phosphorylation Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Positive Regulation Of Myotube Differentiation Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Muscle Cell Differentiation Atrioventricular Node Cell Development	Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle
Pathways		Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription NOTCH2 intracellular domain regulates transcription NOTCH2 intracellular domain regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Formation of paraxial mesoderm	PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Generic Transcription Pathway SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs		None	Alvocidib
GWAS		Dental caries (decayed and filled deciduous teeth) ( 31533690 ) Granulocyte count ( 27863252 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Heel bone mineral density x serum urate levels interaction ( 34046847 ) Monocyte percentage of white cells ( 27863252 ) Neutrophil count ( 27863252 ) Resting heart rate ( 24680774 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 )	Immune response to measles-mumps-rubella vaccine ( 24811271 ) Sporadic pituitary adenoma ( 26029870 )
Interacting Genes		11 interacting genes: CDK8 CREBBP EP300 HDAC9 NOTCH1 NOTCH2 NOTCH3 NOTCH4 PIAS1 RBPJ TP53	39 interacting genes: AURKA BCL6 BMPR1A BUB1 CCNC CCND1 CCNH CDH1 CDKN2B CEBPA CTDP1 ERBB2 ERCC3 ESR1 ESR2 H3C14 KRAS MAML1 MBP MCC MED12 MED21 MED25 MED26 MED8 MED9 MLH3 MYC NRIP1 POLR2A PRMT5 SMAD2 SMAD3 SMARCA4 SREBF1 SUZ12 TOP1 TP53 WDR77
Entrez ID		9794	1024
HPRD ID		05665	04422
Ensembl ID		ENSG00000161021	ENSG00000132964
Uniprot IDs		Q92585	P49336
PDB IDs		2F8X 3NBN 3V79 6SMV	3RGF 4CRL 4F6S 4F6U 4F6W 4F70 4F7J 4F7L 4F7N 4F7S 4G6L 5BNJ 5CEI 5FGK 5HBE 5HBH 5HBJ 5HNB 5HVY 5I5Z 5ICP 5IDN 5IDP 5XQX 5XS2 6QTG 6QTJ 6R3S 6T41 6TPA 6Y0A 8TQ2 8TQC 8TQW 9H8C 9H8S
GO Terms Enriched among Interactors		Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Cardiac Septum Morphogenesis Positive Regulation Of Smooth Muscle Cell Differentiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cell Surface Receptor Signaling Pathway Anatomical Structure Morphogenesis Regulation Of Muscle Cell Differentiation Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Binding Cell Fate Commitment Cell Differentiation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Muscle Cell Differentiation Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Transcription Regulator Complex Histone H3K27 Acetyltransferase Activity Lymphocyte Differentiation Endocardium Morphogenesis Regulation Of Nucleobase-containing Compound Metabolic Process Rhythmic Process Heart Development Cellular Developmental Process Nucleoplasm Transcription Coactivator Activity B Cell Differentiation	Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Initiation Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Mediator Complex Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Differentiation Nucleus Chromatin Binding Transcription Preinitiation Complex Assembly Negative Regulation Of Developmental Process Regulation Of MiRNA Transcription Cell Population Proliferation Animal Organ Development Regulation Of MiRNA Metabolic Process RNA Polymerase II Preinitiation Complex Assembly DNA-templated Transcription Animal Organ Regeneration Positive Regulation Of MiRNA Transcription Core Mediator Complex Liver Development Nucleobase-containing Compound Biosynthetic Process Positive Regulation Of MiRNA Metabolic Process Regulation Of Cell Population Proliferation Gland Development Protein-DNA Complex Assembly Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Cell Differentiation