SPCS2 and STMN3

Number of citations: 0 (PubMedID 16169070)
Data Source: HPRD (two hybrid)

		SPCS2	STMN3
Name		signal peptidase complex subunit 2	stathmin 3
Structure			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Signal Peptidase Complex Endoplasmic Reticulum Membrane Membrane	Cytoplasm Golgi Apparatus Cytosol Axon Growth Cone Cell Projection Neuron Projection
	Molecular Function	Protein Binding	Protein Binding Tubulin Binding Protein Domain Specific Binding
	Biological Process	Signal Peptide Processing Protein Targeting To ER	Blastocyst Hatching Microtubule Depolymerization Nervous System Development Negative Regulation Of Neuron Projection Development Regulation Of Microtubule Polymerization Or Depolymerization Cytoplasmic Microtubule Organization Neuron Projection Development Negative Regulation Of Rac Protein Signal Transduction Regulation Of Cytoskeleton Organization
Pathways		SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Maturation of hRSV A proteins	None
GWAS		No GWAS studies recorded	Allergic disease (asthma, hay fever or eczema) ( 29785011 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 28067908 ) Leukocyte telomere length ( 32109421 ) Mean corpuscular hemoglobin ( 32888494 ) Prostate cancer ( 23535732 ) Refractive error ( 32231278 ) Ulcerative colitis ( 21297633 28067908 )
Interacting Genes		6 interacting genes: ATP13A2 CLN8 EGFR FNDC3B STMN3 TEFM	27 interacting genes: AIRIM ANKRD11 CARD9 CLIC3 EXOC8 GLP1R GPANK1 HGS KAT5 KIFC3 KRT34 LTB4R2 MIPOL1 MKRN3 MNS1 NKX3-1 P4HA3 PLEKHA7 POLR1C SMARCD1 SPCS2 TBC1D21 TRIM69 TRPC5 TXLNB UBQLN1 ZNF76
Entrez ID		9789	50861
HPRD ID		15435	16324
Ensembl ID		ENSG00000118363	ENSG00000197457
Uniprot IDs		Q15005	Q9NZ72
PDB IDs		7P2P 7P2Q	Not available
GO Terms Enriched among Interactors		Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Negative Regulation Of Protein Catabolic Process Shc-EGFR Complex Multivesicular Body, Internal Vesicle Lumen Negative Regulation Of Protein Metabolic Process Somatic Motor Neuron Differentiation Glutamate Reuptake Retinal Rod Cell Apoptotic Process Polyamine Transmembrane Transporter Activity Spermine Transport Extracellular Exosome Biogenesis P-type Transmembrane Transporter Activity Spermine Transmembrane Transport ABC-type Polyamine Transporter Activity Transcription Elongation By Mitochondrial RNA Polymerase Positive Regulation Of Mitochondrial Transcription Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Binding Vacuole Organization Lipid Homeostasis Extracellular Vesicle Biogenesis P-type Ion Transporter Activity Negative Regulation Of Lysosomal Protein Catabolic Process Regulation Of Autophagosome Size Cupric Ion Binding Negative Regulation Of Rac Protein Signal Transduction Retinal Cell Apoptotic Process Polyamine Transmembrane Transport ERBB2-EGFR Signaling Pathway Ceramide Binding Regulation Of Cellular Component Size Regulation Of Neuron Apoptotic Process Regulation Of Chaperone-mediated Autophagy Cellular Response To Manganese Ion Transcription Elongation Factor Activity Crossover Junction DNA Endonuclease Activity Learning Or Memory Salivary Gland Morphogenesis Neurofilament Cytoskeleton Organization L-glutamate Import Across Plasma Membrane ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Regulation Of Lysosomal Protein Catabolic Process Mitochondrial DNA Replication Regulation Of Mitochondrial Transcription	Zonula Adherens Maintenance Adherens Junction Maintenance Zonula Adherens