MTSS1 and RECQL5

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		MTSS1	RECQL5
Name		MTSS I-BAR domain containing 1	RecQ like helicase 5
Structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytoskeleton Cytoplasmic Side Of Plasma Membrane Actin Cytoskeleton Endocytic Vesicle	Nucleus Nucleoplasm Replication Fork Chromosome Cytoplasm Cytosol Transcription Preinitiation Complex
	Molecular Function	Actin Binding Actin Monomer Binding Signaling Receptor Binding Protein Binding Phospholipid Binding Identical Protein Binding	Nucleotide Binding RNA Polymerase II Complex Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity Helicase Activity Protein Binding ATP Binding Four-way Junction Helicase Activity Hydrolase Activity Isomerase Activity ATP Hydrolysis Activity Identical Protein Binding 3'-5' DNA Helicase Activity Metal Ion Binding Catalytic Activity, Acting On DNA
	Biological Process	Plasma Membrane Organization Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Microspike Assembly Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Bundle Assembly Adherens Junction Maintenance Negative Regulation Of Epithelial Cell Proliferation Renal Tubule Morphogenesis Cellular Response To Fluid Shear Stress Glomerulus Morphogenesis Nephron Tubule Epithelial Cell Differentiation Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis	Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination DNA Metabolic Process DNA Replication DNA Repair DNA Recombination Regulation Of DNA-templated Transcription DNA Damage Response Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cell Division Chromosome Separation Cellular Response To Xenobiotic Stimulus Cellular Response To Camptothecin Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Mitotic DNA-templated DNA Replication Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
GWAS		Atrial fibrillation ( 29892015 ) Cognitive function ( 24684796 ) Cognitive performance in schizophrenia or bipolar disorder ( 31872970 ) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444 ) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444 ) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444 ) Dilated cardiomyopathy (MTAG) ( 33495596 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Irritable bowel syndrome ( 29626450 ) Left ventricle diastolic internal dimension ( 28394258 ) Left ventricular ejection fraction ( 31554410 32382064 33495596 ) Left ventricular end-systolic volume ( 32382064 33495596 ) Left ventricular global circumferential strain ( 33495596 )	Appendicular lean mass ( 33097823 ) Deep white matter hyperintensities ( 32517579 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Periventricular white matter hyperintensities ( 32517579 )
Interacting Genes		5 interacting genes: HTT MZF1 PTPRD RBCK1 RECQL5	21 interacting genes: ADCY10P1 ALDH7A1 BNIPL CREB1 CUX1 DDX42 EEF1G ITGB3BP MAPK8IP1 MRE11 MTSS1 MUS81 NBN PCNA PLK1 RAD50 RAD51 STAMBP TIMP1 TOP3A TOP3B
Entrez ID		9788	9400
HPRD ID		12243	04806
Ensembl ID		ENSG00000170873	ENSG00000108469
Uniprot IDs		A5YM41 O43312	B3KQK2 O94762
PDB IDs		2D1K	4BK0 5LB3 5LB5 5LB8 5LBA 7ZML 7ZMM 7ZMN 7ZMO 7ZMP 7ZMQ 7ZMR 7ZMS 7ZMT 7ZMV 8RL5 8RL6 8RL9 8RLA 9EI1 9EI2 9EI3 9EI4
GO Terms Enriched among Interactors		Regulation Of CAMKK-AMPK Signaling Cascade Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Aggrephagy Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Lipophagy Positive Regulation Of CAMKK-AMPK Signaling Cascade Phosphoprotein Phosphatase Activity Identical Protein Binding Trans-synaptic Signaling By Trans-synaptic Complex Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Mitotic DNA Replication Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Nuclear DNA Replication Catalytic Activity, Acting On DNA Four-way Junction Helicase Activity Cellular Response To Camptothecin Mitotic DNA-templated DNA Replication LUBAC Complex Protein Linear Polyubiquitination Vocal Learning Regulation Of Organelle Assembly Observational Learning Presynaptic Membrane Assembly Profilin Binding Presynaptic Membrane Organization Chromosome Separation Presynapse Assembly 3'-5' DNA Helicase Activity Transcription Preinitiation Complex Ubiquitin Ligase Activator Activity Auditory Behavior Positive Regulation Of Cell Projection Organization Dynactin Binding Mechanosensory Behavior Regulation Of Postsynaptic Density Assembly Regulation Of Apoptotic Signaling Pathway Transmembrane Receptor Protein Tyrosine Phosphatase Activity	Recombinational Repair Chromosome Organization Double-strand Break Repair Via Homologous Recombination DNA Recombination Telomere Maintenance DNA Repair DNA Strand Elongation Double-strand Break Repair Chromosomal Region Telomeric 3' Overhang Formation Telomere Organization Mre11 Complex BRCA1-C Complex Replication Fork Chromosome, Telomeric Region DNA Metabolic Process Homologous Recombination R-loop Processing DNA Damage Response Regulation Of DNA Repair Meiotic Cell Cycle Mitotic G2/M Transition Checkpoint DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Recombination Regulation Of Double-strand Break Repair Mitotic DNA Damage Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle G2/M Phase Transition DNA Double-strand Break Processing Negative Regulation Of Mitotic Cell Cycle Reciprocal Meiotic Recombination Cellular Response To Stress Site Of Double-strand Break DNA Damage Checkpoint Signaling Nucleus Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity PML Body Mitotic G2 DNA Damage Checkpoint Signaling Chromosome Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G2/M Phase Transition Replication Fork Processing Negative Regulation Of Cell Cycle Process Negative Regulation Of DNA Metabolic Process Regulation Of DNA Metabolic Process Positive Regulation Of DNA Repair