RASSF2 and PRMT3

Number of citations: 0 (PubMedID 23455924)
Data Source: BioGRID (two hybrid)

		RASSF2	PRMT3
Name		Ras association domain family member 2	protein arginine methyltransferase 3
Structure		No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Chromosome Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Protein-containing Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Kinase Activity Protein Binding	Protein Binding Methyltransferase Activity Zinc Ion Binding Protein-arginine N-methyltransferase Activity Transferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Histone H4R3 Methyltransferase Activity Metal Ion Binding
	Biological Process	Skeletal System Development Ossification Signal Transduction Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein Autophosphorylation Negative Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Apoptotic Process Regulation Of Osteoblast Differentiation Regulation Of Osteoclast Differentiation Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Bone Remodeling Homeostasis Of Number Of Cells Protein Stabilization Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Non-canonical NF-kappaB Signal Transduction	Chromatin Remodeling Regulation Of DNA-templated Transcription Negative Regulation Of Protein Ubiquitination Methylation Positive Regulation Of Osteoblast Differentiation Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of Retinoic Acid Biosynthetic Process
Pathways		None	RMTs methylate histone arginines Protein methylation
Drugs		None	S-adenosyl-L-homocysteine
GWAS		Refractive error ( 32231278 ) Suicide attempt severity in mood disorders ( 33783297 ) Systemic lupus erythematosus ( 24871463 )	Carotid intima media thickness (maximum) ( 31801372 ) Number of alcoholic drinks required to feel an effect (long-term average) ( 31270906 ) Pursuit maintenance gain ( 29064472 ) Response to inhaled glucocorticoid treatment in asthma (change in FEV1) ( 25601762 )
Interacting Genes		8 interacting genes: HRAS KDM1A KRAS PRMT3 PRMT6 RASSF5 S100Z SUV39H1	11 interacting genes: BEND7 FBL HNRNPA1 MEOX2 PABPN1 PIH1D2 PPARD RASSF2 STAT1 TMEM132D TSC22D2
Entrez ID		9770	10196
HPRD ID		15218	11934
Ensembl ID		ENSG00000101265	ENSG00000185238
Uniprot IDs		P50749	O60678 Q8WUV3
PDB IDs		Not available	2FYT 3SMQ 4HSG 4QQN 4RYL 8G2F 8G2G 8SHB 8SHR 8SIO
GO Terms Enriched among Interactors		Histone Methyltransferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Histone H4R3 Methyltransferase Activity Glial Cell Development Protein-arginine Omega-N Asymmetric Methyltransferase Activity Protein-arginine N-methyltransferase Activity Regulation Of Multicellular Organismal Process Histone H3 Methyltransferase Activity Cellular Response To Gamma Radiation Regulation Of Long-term Neuronal Synaptic Plasticity Methyltransferase Activity Protein-membrane Adaptor Activity Methylation Regulation Of Protein Ubiquitination Regulation Of Neuronal Synaptic Plasticity Response To Gamma Radiation Positive Regulation Of Gene Expression MAPK Cascade Regulation Of Cellular Senescence Positive Regulation Of Neurogenesis Positive Regulation Of Nervous System Development Ventral Spinal Cord Interneuron Fate Determination Type B Pancreatic Cell Fate Commitment Chromatin Remodeling Epigenetic Regulation Of Gene Expression Regulation Of Post-translational Protein Modification Histone H2AR3 Methyltransferase Activity Cellular Senescence Positive Regulation Of Gliogenesis Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription GDP Binding G Protein Activity Regulation Of Macromolecule Metabolic Process Cellular Response To Ionizing Radiation Regulation Of RNA Biosynthetic Process GTPase Complex Ras Protein Signal Transduction Regulation Of Multicellular Organismal Development Pancreatic A Cell Fate Commitment Pancreatic PP Cell Fate Commitment Negative Regulation Of Retinoic Acid Biosynthetic Process Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Histone H3R2 Methyltransferase Activity Regulation Of Cell Development Regulation Of Neurogenesis Chromatin Organization Positive Regulation Of Cell Population Proliferation Phospholipase C Activator Activity	Ribonucleoprotein Complex