ECE2 and CD86

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		ECE2	CD86
Name		endothelin converting enzyme 2	CD86 molecule
Structure		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Plasma Membrane Membrane Transport Vesicle Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Centriolar Satellite Extracellular Exosome
	Molecular Function	Catalytic Activity Metalloendopeptidase Activity Protein Binding Methyltransferase Activity Peptidase Activity Metallopeptidase Activity Transferase Activity Hydrolase Activity Metal Ion Binding	Virus Receptor Activity Protein Binding Coreceptor Activity Signaling Receptor Activity Receptor Ligand Activity
	Biological Process	Proteolysis G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Protein Processing Peptide Hormone Processing Methylation	Adaptive Immune Response Immune System Process Positive Regulation Of Immunoglobulin Production Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation T Cell Costimulation Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Lymphotoxin A Production Positive Regulation Of T Cell Proliferation T Cell Activation B Cell Activation Negative Regulation Of T Cell Proliferation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of DNA-templated Transcription Lymphocyte Activation Symbiont Entry Into Host Cell Cellular Response To Lipopolysaccharide Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		Peptide ligand-binding receptors	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer Co-stimulation by CD28 CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway Co-inhibition by CTLA4 Interleukin-10 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs		None	Antithymocyte immunoglobulin (rabbit) Abatacept Belatacept Bryostatin 1
GWAS		Body mass index ( 29273807 ) Daytime nap ( 33568662 ) Major depressive disorder ( 22472876 ) Menarche (age at onset) ( 21102462 )	Autoimmune thyroid disease ( 32581359 ) Diffuse large B cell lymphoma ( 25261932 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Follicular lymphoma ( 25279986 ) Gut microbiota (functional units) ( 27694959 ) Multiple sclerosis ( 21833088 22190364 24076602 27386562 31604244 ) Selective IgA deficiency ( 27723758 ) Systemic lupus erythematosus ( 19838195 ) Type 2 diabetes ( 30718926 )
Interacting Genes		8 interacting genes: CASP10 CD53 CD86 FOXP1 LCOR MTNR1A SYNE4 UBC	6 interacting genes: CD28 CD80 CTLA4 ECE2 MARCHF8 PARP1
Entrez ID		9718	942
HPRD ID		09931	03011
Ensembl ID		ENSG00000145194	ENSG00000114013
Uniprot IDs		P0DPD6	A0A0X9R4E0 A8K632 P42081
PDB IDs		Not available	1I85 1NCN 5YXK 8FXX 8FXY 8HXB 8HXC
GO Terms Enriched among Interactors		None	Protein Complex Involved In Cell Adhesion Regulation Of Lymphocyte Differentiation Regulation Of DNA Metabolic Process NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity Response To Aldosterone NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of DNA Recombination NAD+-protein-histidine ADP-ribosyltransferase Activity Response To Mineralocorticoid Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Circadian Sleep/wake Cycle NAD+-protein-tyrosine ADP-ribosyltransferase Activity Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation T Cell Costimulation Regulation Of T Cell Proliferation Regulation Of B Cell Activation Regulation Of Cell Development Regulation Of Regulatory T Cell Differentiation Regulation Of Lymphocyte Activation Regulation Of Hemopoiesis Positive Regulation Of Interleukin-2 Production Regulation Of T Cell Differentiation Negative Regulation Of Cell Activation Negative Regulation Of Lymphocyte Activation Negative Regulation Of Leukocyte Activation Negative Regulation Of B Cell Activation Activin A Complex Androst-4-ene-3,17-dione Biosynthetic Process Thyrotropin-releasing Hormone Activity Negative Regulation Of Immune System Process Coreceptor Activity Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Lymphocyte Differentiation Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Myofibroblast Differentiation Regulation Of Cell Differentiation NAD+-protein-serine ADP-ribosyltransferase Activity Regulation Of Interleukin-2 Production Regulation Of Leukocyte Proliferation Cardiac Fibroblast Cell Development Type II Activin Receptor Binding Inhibin A Complex Positive Regulation Of Ovulation Progesterone Secretion Positive Regulation Of DNA Recombination Regulation Of Behavior Transcription By RNA Polymerase II Positive Regulation Of Alpha-beta T Cell Activation