TRAM2 and GTF2B

Number of citations: 41 (PubMedID 14612417)
Data Source: HPRD (in vivo)

		TRAM2	GTF2B
Name		translocation associated membrane protein 2	general transcription factor IIB
Structure		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Membrane	Kinetochore Condensed Chromosome Nucleus Nucleoplasm Transcription Factor TFIID Complex Chromosome Nuclear Body Cell Division Site Protein-DNA Complex Germinal Vesicle RNA Polymerase II Transcription Regulator Complex Transcription Preinitiation Complex
	Molecular Function	Protein Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Complex Binding DNA Binding Histone Acetyltransferase Activity Protein Binding Zinc Ion Binding RNA Polymerase II General Transcription Initiation Factor Activity Acetyltransferase Activity Transferase Activity Acyltransferase Activity TBP-class Protein Binding Metal Ion Binding Nuclear Thyroid Hormone Receptor Binding Protein-lysine-acetyltransferase Activity DNA-binding Transcription Factor Binding Promoter-specific Chromatin Binding
	Biological Process	SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Protein Transport Collagen Biosynthetic Process Protein Insertion Into ER Membrane	Transcriptional Start Site Selection At RNA Polymerase II Promoter Chromatin Remodeling DNA-templated Transcription Initiation Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Protein Acetylation Gene Expression Viral Transcription RNA Polymerase II Preinitiation Complex Assembly Meiotic Sister Chromatid Cohesion Spindle Assembly Chromosome Organization Transcription Preinitiation Complex Assembly Positive Regulation Of Core Promoter Binding RNA Polymerase II Core Complex Assembly
Pathways		None	HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance
GWAS		Apolipoprotein B levels ( 32203549 ) Appendicular lean mass ( 33097823 ) Atopic march ( 26542096 ) Intraocular pressure ( 29617998 ) LDL cholesterol levels ( 28334899 ) Lipid traits (pleiotropy) (HIPO component 2) ( 30289880 ) Low density lipoprotein cholesterol levels ( 29083408 ) Total cholesterol levels ( 28334899 )	Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143 ) Hematocrit ( 32888494 ) Intraocular pressure ( 29617998 ) Obesity-related traits ( 23251661 ) Pulse pressure ( 30578418 ) Rosacea symptom severity ( 29771307 ) Systolic blood pressure ( 28135244 30578418 )
Interacting Genes		4 interacting genes: GTF2B GTF2F2 POLR2A TBP	56 interacting genes: ADRB2 ATF4 BCL3 CIITA CREBBP CTBP1 DEPDC7 DHX9 DRAP1 EP300 ESR1 ESRRA FBXO25 FOXF2 GOLGA6L9 GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H4 HMGCL HNF4A HSF1 IKZF1 JAK3 JUN KLF5 MCM2 MECP2 NCOA1 NCOA3 NCOA4 NCOR1 NOLC1 NR1D2 NR2F1 NR5A1 POLR2A POU3F2 PSMC2 PSMC5 REL RELA REST SLC22A2 SRA1 TAF11 TAF9 TBP TBPL1 TCEA2 THRA TNIP1 TRAM2 VDR YWHAE
Entrez ID		9697	2959
HPRD ID		16338	08928
Ensembl ID		ENSG00000065308	ENSG00000137947
Uniprot IDs		A0A024RD84 Q15035	Q00403
PDB IDs		Not available	1C9B 1DL6 1RLY 1RO4 1TFB 1VOL 2PHG 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 5WH1 6O9L 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 7NVS 7NVT 7NVU 7NVY 7NVZ 7NW0 7ZWC 7ZWD 7ZX7 7ZX8 7ZXE 8BVW 8BYQ 8BZ1 8GXQ 8GXS 8S51 8S52 8S5N 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS
GO Terms Enriched among Interactors		RNA Polymerase II General Transcription Initiation Factor Activity Transcription Initiation At RNA Polymerase II Promoter Transcription By RNA Polymerase II DNA-templated Transcription Initiation DNA-templated Transcription RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor TFIID Complex Nucleobase-containing Compound Biosynthetic Process Transcription Elongation By RNA Polymerase II MRNA Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly DNA-templated Transcription Elongation MRNA Transcription Transcription Preinitiation Complex Assembly Promoter-specific Chromatin Binding RNA Metabolic Process Macromolecule Biosynthetic Process Transcriptional Start Site Selection At RNA Polymerase II Promoter RNA Polymerase II, Holoenzyme RNA Polymerase II Core Complex Assembly RNA Polymerase II Transcription Regulator Complex Transcription Factor TFIIF Complex Positive Regulation Of Core Promoter Binding Nucleic Acid Metabolic Process RNA-directed RNA Polymerase Activity RNA-templated Transcription DNA Binding DNA-binding Transcription Factor Binding Germinal Vesicle Protein-DNA Complex Assembly TFIIB-class Transcription Factor Binding Microfibril Binding RNA Polymerase Transcription Factor SL1 Complex Transcription Factor TFIIA Complex Viral Transcription 5'-3' RNA Polymerase Activity RNA Polymerase II General Transcription Initiation Factor Binding Pronucleus Nucleobase-containing Compound Metabolic Process Male Pronucleus Aryl Hydrocarbon Receptor Binding Lung-associated Mesenchyme Development RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I Preinitiation Complex Assembly Female Pronucleus Meiotic Sister Chromatid Cohesion Positive Regulation Of Transcription Regulatory Region DNA Binding Axon Guidance Receptor Activity RNA Polymerase III General Transcription Initiation Factor Activity Transcription Preinitiation Complex	Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Transcription By RNA Polymerase II DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA Binding Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II General Transcription Initiation Factor Activity Positive Regulation Of Macromolecule Metabolic Process Nucleus Nucleobase-containing Compound Biosynthetic Process Regulation Of Primary Metabolic Process General Transcription Initiation Factor Binding Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Chromatin Regulation Of Macromolecule Metabolic Process RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Intracellular Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Transcription By RNA Polymerase II Regulation Of Metabolic Process Nuclear Receptor Activity Transcription Factor TFIID Complex RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nucleic Acid Metabolic Process MRNA Transcription Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Biosynthetic Process Hormone-mediated Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Transcription Coactivator Activity