UBE3C and MTA2

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		UBE3C	MTA2
Name		ubiquitin protein ligase E3C	metastasis associated 1 family member 2
Structure			No pdb structure
GO Annotations	Cellular Component	Proteasome Complex	Histone Deacetylase Complex Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Membrane NuRD Complex Protein-containing Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity	DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Zinc Ion Binding Nucleosomal DNA Binding Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding
	Biological Process	Autophagosome Assembly Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein K29-linked Ubiquitination Phosphatidylinositol Phosphate Biosynthetic Process Protein K48-linked Ubiquitination	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Fibroblast Migration Regulation Of Cell Fate Specification Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Genomic Imprinting Regulation Of Stem Cell Differentiation
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
GWAS		Body mass index ( 25673413 ) Language impairment in frontotemporal lobe dementia ( 29724592 ) Quantitative traits ( 19197348 ) Response to citalopram treatment ( 19846067 ) Type 2 diabetes ( 30054458 )	Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Interacting Genes		17 interacting genes: APP BIRC6 CAND2 CCNB1 DOT1L GOLGA2 GRSF1 MTA2 PIK3C3 PSMC5 PSMD2 TLK1 TP73 UBE2D1 UBE2D2 UBE2D3 UBE2L3	24 interacting genes: APPL1 APPL2 CEBPA CUL4B DDB1 ERCC6 ESR1 FKBP3 H3-4 HNRNPD MBD3 MED30 NACC2 RBBP4 RBBP7 SATB1 SATB2 SPEN SUMO2 TP53 TSC22D3 UBE3C USP11 YY1
Entrez ID		9690	9219
HPRD ID		15604	07233
Ensembl ID		ENSG00000009335	ENSG00000149480
Uniprot IDs		Q15386	O94776
PDB IDs		6K2C	Not available
GO Terms Enriched among Interactors		Ubiquitin Conjugating Enzyme Activity Macromolecule Metabolic Process Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Ubiquitin-protein Transferase Activity Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of RNA Metabolic Process Protein Ubiquitination Regulation Of Macromolecule Metabolic Process Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Protein Modification Process Proteolysis Proteasome Regulatory Particle, Base Subcomplex Proteasome Regulatory Particle Positive Regulation Of Protein Metabolic Process Protein Tetramerization Post-translational Protein Modification Transferase Activity Proteasome Accessory Complex Protein Polyubiquitination Protein K48-linked Ubiquitination Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus ATP Binding Catabolic Process TBP-class Protein Binding Ubiquitin Protein Ligase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Cell Cycle Positive Regulation Of Protein Modification Process Spindle Pole Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Protein-containing Complex DNA-binding Transcription Factor Binding Protein K11-linked Ubiquitination	Chromatin Remodeling Chromatin Organization Nucleus Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Histone Deacetylase Binding Negative Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Nuclear Matrix DNA Binding Negative Regulation Of Macromolecule Metabolic Process NuRD Complex Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macropinocytosis Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Response To UV Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Binding Positive Regulation Of DNA-templated Transcription Initiation Negative Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Fate Specification Regulation Of DNA-templated Transcription Initiation Cellular Response To UV Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Light Stimulus Transcription Regulator Complex Macropinosome Nuclear Lumen Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Phase Transition Cul4B-RING E3 Ubiquitin Ligase Complex