SH3PXD2A and ADAM15

Number of citations: 24 (PubMedID 16374509)
Data Source: BioGRID (pull down, affinity chromatography technology), HPRD (in vitro)

		SH3PXD2A	ADAM15
Name		SH3 and PX domains 2A	ADAM metallopeptidase domain 15
Structure			No pdb structure
GO Annotations	Cellular Component	Podosome Cytoplasm Cytosol Cell Projection Anchoring Junction	Acrosomal Vesicle Extracellular Space Plasma Membrane Adherens Junction Cilium Cell Surface Endomembrane System Membrane Cytoplasmic Vesicle Motile Cilium Cell Projection Extracellular Exosome Anchoring Junction
	Molecular Function	Protease Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-5-phosphate Binding Superoxide-generating NADPH Oxidase Activator Activity Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-4-phosphate Binding	Metalloendopeptidase Activity Integrin Binding Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity SH3 Domain Binding Immunoglobulin Receptor Binding Metal Ion Binding
	Biological Process	In Utero Embryonic Development Superoxide Metabolic Process Superoxide Anion Generation Reactive Oxygen Species Metabolic Process Osteoclast Fusion	Angiogenesis Negative Regulation Of Cell-matrix Adhesion Immune Response To Tumor Cell Proteolysis Apoptotic Process Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Male Gonad Development Extracellular Matrix Disassembly Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Collagen Catabolic Process Tissue Regeneration Innate Immune Response Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Receptor Binding Cellular Response To Phorbol 13-acetate 12-myristate Response To Hypobaric Hypoxia
Pathways		Invadopodia formation CDC42 GTPase cycle	Degradation of the extracellular matrix Invadopodia formation
GWAS		Atrial fibrillation ( 33990960 29892015 28416818 28416822 29290336 ) Brain morphology (MOSTest) ( 32665545 ) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143 ) Cutaneous malignant melanoma ( 26237428 ) Diisocyanate-induced asthma ( 25918132 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Intraocular pressure ( 29617998 ) Manganese levels ( 26025379 ) Periventricular white matter hyperintensities ( 32517579 ) PR interval ( 32439900 30046033 ) Refractive error ( 32231278 ) Rheumatoid arthritis ( 30891314 ) Telomere length ( 33941849 ) Waist circumference adjusted for body mass index ( 28552196 ) White matter hyperintensities ( 32358547 ) White matter hyperintensity burden ( 25663218 ) White matter hyperintensity volume ( 33293549 ) White matter hyperintensity volume (adjusted for hypertension) ( 33293549 ) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549 )	Bipolar disorder ( 31043756 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Chin dimples ( 27182965 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (min-P) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Eosinophil percentage of white cells ( 32888494 ) General risk tolerance (MTAG) ( 30643258 ) Hip circumference adjusted for BMI ( 34021172 ) Mosquito bite size ( 28199695 ) Prostate cancer ( 23535732 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Systemic lupus erythematosus ( 28714469 ) Walking pace ( 33128006 )
Interacting Genes		7 interacting genes: ADAM15 AFAP1L2 FASLG KHDRBS1 PAK2 SRC SVIL	34 interacting genes: ABL1 ARHGEF6 ARHGEF7 ATXN1 BANP FHL3 FYN GRB2 HCK LCK LYN MAD2L2 NCK1 NPHP1 NUP62 ODAM PACSIN3 RBPMS SH3D19 SH3GL2 SH3GLB1 SH3PXD2A SH3RF1 SH3RF3 SNX30 SNX33 SNX9 SORBS1 SORBS2 SORBS3 SP4 SRC TRIP13 YES1
Entrez ID		9644	8751
HPRD ID		10228	05674
Ensembl ID		ENSG00000107957	ENSG00000143537
Uniprot IDs		B3KPL1 B7Z9L8 Q5TCZ1	Q13444
PDB IDs		2DNU 2EGA 2EGC 2EKH	Not available
GO Terms Enriched among Interactors		Protein Tyrosine Kinase Activator Activity SH2 Domain Binding SH3 Domain Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of Cell-matrix Adhesion Podosome Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Cell Surface Receptor Signaling Pathway Response To Growth Factor Immune System Process Regulation Of ERBB Signaling Pathway Caveola Cellular Response To Transforming Growth Factor Beta Stimulus Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Response To Transforming Growth Factor Beta Negative Regulation Of Cell-substrate Adhesion Grb2-Sos Complex Anchoring Junction Immune Response-regulating Signaling Pathway Focal Adhesion Activation Of Immune Response Integrin-mediated Signaling Pathway Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Regulation Of Cellular Component Organization Protein Autophosphorylation Regulation Of Cell-matrix Adhesion Retinal Cell Programmed Cell Death Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Negative Regulation Of Protein-containing Complex Assembly Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Programmed Cell Death Cytoplasmic Vesicle Lumen Negative Regulation Of Cytoskeleton Organization Integrin Binding Cellular Response To Progesterone Stimulus Negative Regulation Of Receptor Binding Response To Hypobaric Hypoxia Negative Regulation Of Supramolecular Fiber Organization Cell-substrate Adhesion	Fc-gamma Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Non-membrane Spanning Protein Tyrosine Kinase Activity Fc Receptor Mediated Stimulatory Signaling Pathway Ephrin Receptor Signaling Pathway Fc Receptor Signaling Pathway Ephrin Receptor Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Costimulation Regulation Of Cellular Component Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Component Organization Cytoplasm Positive Regulation Of Cellular Component Biogenesis Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Organelle Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Protein Tyrosine Kinase Activity Cytosol Positive Regulation Of Lymphocyte Activation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Immune Response-activating Signaling Pathway Phosphotyrosine Residue Binding Positive Regulation Of Organelle Organization Positive Regulation Of T Cell Activation Regulation Of MAPK Cascade Peptidyl-tyrosine Phosphorylation Regulation Of Lymphocyte Activation Positive Regulation Of Metabolic Process Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Leukocyte Cell-cell Adhesion Anchoring Junction Immune Response-regulating Signaling Pathway Activation Of Immune Response Positive Regulation Of Proteolysis Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of MAPK Cascade Positive Regulation Of Cell-cell Adhesion Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Protein Metabolic Process Regulation Of Cell Activation Positive Regulation Of Cell Adhesion Antigen Receptor-mediated Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of Immune Response