FEZ1 and UBE4B

Number of citations: 0 (PubMedID 15466860)
Data Source: BioGRID (enzymatic study)

		FEZ1	UBE4B
Name		fasciculation and elongation protein zeta 1	ubiquitination factor E4B
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Centrosome Cytoskeleton Microtubule Plasma Membrane Membrane Axon Dendrite Growth Cone Cell Projection Neuronal Cell Body	Ubiquitin Ligase Complex Nucleus Cytoplasm
	Molecular Function	Protein Kinase C Binding Protein Binding Gamma-tubulin Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Enzyme Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Mitochondrion Organization Cell Adhesion Nervous System Development Axon Guidance Positive Regulation Of Neuron Projection Development Hippocampus Development Establishment Of Cell Polarity Establishment Of Mitochondrion Localization Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Cellular Response To Growth Factor Stimulus Negative Regulation Of Autophagosome Assembly	Protein Polyubiquitination Ventricular Trabecula Myocardium Morphogenesis Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Granzyme-mediated Apoptotic Signaling Pathway Response To UV Protein Ubiquitination Protein Catabolic Process Neuron Projection Development Response To Endoplasmic Reticulum Stress ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination
GWAS		Alanine aminotransferase levels ( 34315874 ) Aspartate aminotransferase levels ( 34315874 ) Breast cancer (survival) ( 25890600 ) Schizophrenia ( 22688191 23894747 )	Atrial fibrillation ( 29892015 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Hemoglobin levels ( 33491795 ) Hepatocellular carcinoma ( 20676096 ) Hip circumference adjusted for BMI ( 34021172 ) Resting heart rate ( 27798624 )
Interacting Genes		60 interacting genes: BARD1 BORA BRD1 C8orf33 CCL7 CEP126 CIB1 CLASP2 COL9A2 CSTF2 DIS3L2 DISC1 DNAAF5 DRAP1 DYRK1A FEZ2 GEMIN7 GTF2F1 HAP1 HTATSF1 HTT IMMT LRIF1 MEST NBR1 NDUFB9 NEK1 NRIP1 OLFML3 P4HB PAM16 PCNT PDCD7 PPP4R3B PRKCZ PTH PTN PTPRS RAB3GAP1 RAB3GAP2 RAI14 RIF1 SAP30L SCOC SERPINH1 SMARCD1 SMC3 STAR TAC3 TAF1D TAF9 TBC1D25 TEDC2 TLK2 TOMM20 TTR TXNDC9 UBE4B WWC1 ZNF251	27 interacting genes: ATXN3 CASP3 CASP6 CASP7 CDKN2A CNTN2 DNAJC7 ESR1 FEZ1 GZMB HGS HRAS MAPK3 OTUB1 PGAM5 PPP3CA PRMT1 PYCR2 RAD23A RIPK4 TP53 TRA2A TRIP12 UBE2D2 UBE2D3 VAV2 VCP
Entrez ID		9638	10277
HPRD ID		09212	11659
Ensembl ID		ENSG00000149557	ENSG00000130939
Uniprot IDs		Q99689	O95155
PDB IDs		Not available	2KRE 3L1X 3L1Z 5O75
GO Terms Enriched among Interactors		Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Autophagosome Microtubule Cytoskeleton Organization Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Regulation Of Cellular Response To Stress Centrosome Regulation Of Macroautophagy Microtubule Cytoskeleton Organization Involved In Mitosis Microtubule-based Process Positive Regulation Of Protein Lipidation Cytoskeleton Regulation Of Endoplasmic Reticulum Tubular Network Organization RNA Polymerase II General Transcription Initiation Factor Binding Regulation Of Protein Lipidation Regulation Of Organelle Assembly Regulation Of Microtubule-based Process RNA Polymerase II General Transcription Initiation Factor Activity Positive Regulation Of Macroautophagy Positive Regulation Of Organelle Assembly Regulation Of Autophagy Microtubule Organizing Center Mitotic Spindle Organization Axon Negative Regulation Of Microtubule Polymerization Or Depolymerization Chondroitin Sulfate Binding Regulation Of Autophagosome Assembly Regulation Of Organelle Organization	Catabolic Process Cytosol Cellular Response To Staurosporine Proteolysis DNA Damage Response Protein Metabolic Process Macromolecule Catabolic Process Protein Catabolic Process Protein Modification Process Nucleoplasm Response To Stress Pyroptotic Inflammatory Response Positive Regulation Of Intracellular Signal Transduction Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Metabolic Process Programmed Cell Death DNA Repair Cell Death Intracellular Signal Transduction Regulation Of Protein Metabolic Process Cysteine-type Peptidase Activity Regulation Of Proteolysis Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stress Macromolecule Metabolic Process Regulation Of Metabolic Process Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Regulation Of Primary Metabolic Process TORC1 Signaling Negative Regulation Of TORC1 Signaling Post-translational Protein Modification Positive Regulation Of Neuron Apoptotic Process Nucleic Acid Metabolic Process Macroautophagy Apoptotic Process Autophagy Regulation Of Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling TOR Signaling Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of TOR Signaling DNA Metabolic Process Regulation Of Signal Transduction Regulation Of Cellular Response To Stress Regulation Of TORC1 Signaling Regulation Of Macromolecule Metabolic Process