ISG15 and UBA7

Number of citations: 0 (PubMedID 16169070)
Data Source: HPRD (two hybrid, in vivo)

		ISG15	UBA7
Name		ISG15 ubiquitin like modifier	ubiquitin like modifier activating enzyme 7
Structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Integrin Binding Protein Binding Protein Tag Activity Ubiquitin Protein Ligase Binding	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin-like Modifier Activating Enzyme Activity Ligase Activity ISG15 Activating Enzyme Activity
	Biological Process	Immune System Process Regulation Of Immune System Process Integrin-mediated Signaling Pathway Response To Virus Response To Bacterium Protein Ubiquitination Modification-dependent Protein Catabolic Process Positive Regulation Of Bone Mineralization Negative Regulation Of Protein Ubiquitination ISG15-protein Conjugation Positive Regulation Of Protein Oligomerization Regulation Of Type II Interferon Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-10 Production Response To Type I Interferon Defense Response To Bacterium Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Multicellular Organismal Process Defense Response To Virus Negative Regulation Of Type I Interferon-mediated Signaling Pathway Protein Localization To Mitochondrion	DNA Damage Response Protein Ubiquitination Modification-dependent Protein Catabolic Process ISG15-protein Conjugation Innate Immune Response
Pathways		ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Interferon alpha/beta signaling Negative regulators of DDX58/IFIH1 signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses RSV-host interactions PKR-mediated signaling Modulation of host responses by IFN-stimulated genes	ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Negative regulators of DDX58/IFIH1 signaling Antigen processing: Ubiquitination & Proteasome degradation Modulation of host responses by IFN-stimulated genes
GWAS		Blood protein levels ( 30072576 )	Body mass index ( 26426971 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Extremely high intelligence ( 29520040 ) Menarche (age at onset) ( 25231870 ) Refractive error ( 32231278 ) Regular attendance at a gym or sports club ( 29970889 ) Regular attendance at a religious group ( 29970889 ) Sleep duration (short sleep) ( 30846698 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Ulcerative colitis ( 21297633 ) Waist circumference adjusted for body mass index ( 34021172 )
Interacting Genes		25 interacting genes: BRAP CBX5 DDOST FUS GRPEL1 HDAC6 HIF1A KLHL26 MRTO4 NAP1L1 NCL PFN1 RPL23 RPL3 RPN2 SUMO1 TPM3 TPM4 TUBA1B UBA7 USP14 USP16 USP18 USP21 USP5	7 interacting genes: FAS ISG15 LCOR RSPH1 UBE2E1 UBE2L3 UBE2L6
Entrez ID		9636	7318
HPRD ID		00958	01873
Ensembl ID		ENSG00000187608	ENSG00000182179
Uniprot IDs		P05161	P41226
PDB IDs		1Z2M 2HJ8 3PHX 3PSE 3R66 3RT3 3SDL 5TL6 5W8T 5W8U 6BI8 6FFA 6XA9 7RBS 7S6P 8OIF 8SE9 8SEA 8SEB 8SV8	8OIF 8SE9 8SEA 8SEB 8SV8 8WWX
GO Terms Enriched among Interactors		Cysteine-type Deubiquitinase Activity Protein Deubiquitination Regulation Of Protein Stability Protein Modification By Small Protein Removal Cysteine-type Peptidase Activity Protein Metabolic Process Post-translational Protein Modification Protein Modification Process Presynaptic Cytosol Muscle Thin Filament Tropomyosin Oligosaccharyltransferase Complex B Macromolecule Metabolic Process Positive Regulation Of Epithelial Cell Migration Negative Regulation Of Proteolysis Ubiquitin Protein Ligase Binding Oligosaccharyltransferase Complex A Cytoplasm Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Cysteine-type Endopeptidase Activity Regulation Of Epithelial Cell Migration Oligosaccharyltransferase Complex Negative Regulation Of Catabolic Process Axonal Transport Of Mitochondrion Adenyl-nucleotide Exchange Factor Activity Regulation Of Proteolysis Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Nucleolus Peptidase Activity Ubiquitin Binding Cellular Response To Interleukin-4 Deubiquitinase Activity Protein K48-linked Deubiquitination Mitochondrion Transport Along Microtubule Response To Interleukin-4 Postsynaptic Cytosol Histone Deacetylase Binding Response To Cytokine RNA Binding Regulation Of Protein Metabolic Process Establishment Of Mitochondrion Localization Response To Peptide Proteolysis Positive Regulation Of Gene Expression Negative Regulation Of Protein Metabolic Process ISG15 Activating Enzyme Activity Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation Positive Regulation Of Ribosome Biogenesis Hsp90 Protein Binding	ISG15-protein Conjugation Ubiquitin Conjugating Enzyme Activity ISG15 Transferase Activity Ubiquitin-like Protein Transferase Activity Modification-dependent Protein Catabolic Process Protein Ubiquitination Ubiquitin-protein Transferase Activity Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Polyubiquitination Post-translational Protein Modification Macromolecule Catabolic Process Fas Signaling Pathway Ubiquitin Ligase Complex Proteolysis Radial Spoke Head 1 Radial Spoke Head 3 Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Oligomerization Cellular Response To Hyperoxia Radial Spoke Head CD95 Death-inducing Signaling Complex Death-inducing Signaling Complex Activation-induced Cell Death Of T Cells Outer Dense Fiber Regulation Of Protein Ubiquitination Necroptotic Signaling Pathway Protein Modification Process Ubiquitin-protein Transferase Activator Activity