CYTIP and CYTH1

Number of citations: 43 (PubMedID 12606567)
Data Source: HPRD (two hybrid, in vitro)

		CYTIP	CYTH1
Name		cytohesin 1 interacting protein	cytohesin 1
Structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Cell Cortex	Golgi Membrane Cytoplasm Cytosol Plasma Membrane Adherens Junction Bicellular Tight Junction Cytoplasmic Side Of Plasma Membrane Membrane Anchoring Junction
	Molecular Function	Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Lipid Binding
	Biological Process	Regulation Of Cell Adhesion	Vesicle-mediated Transport Regulation Of Cell Adhesion Regulation Of ARF Protein Signal Transduction Establishment Of Epithelial Cell Polarity
Pathways		None	Intra-Golgi traffic
GWAS		Type 2 diabetes ( 30297969 ) Urate levels ( 31578528 )	Anxiety and major depressive disorder ( 24047446 ) Atrial fibrillation ( 30061737 ) HDL cholesterol levels ( 32203549 ) Pulse pressure ( 27841878 30578418 ) Red cell distribution width ( 32888494 ) Systolic blood pressure ( 27841878 )
Interacting Genes		9 interacting genes: ARX CYTH1 CYTH2 CYTH3 KIF9 MCRS1 SCNM1 SHANK3 SOCS1	13 interacting genes: ACTA1 ARF1 ARF6 ARFRP1 CYTIP FOSL2 GNAQ ITGB2 ITSN1 PCNT PRKCD SNAPC5 TRIM23
Entrez ID		9595	9267
HPRD ID		09192	01630
Ensembl ID		ENSG00000115165	ENSG00000108669
Uniprot IDs		O60759	B7Z9W0 K7ENQ8 Q15438
PDB IDs		2Z17	1BC9 4A4P
GO Terms Enriched among Interactors		Regulation Of ARF Protein Signal Transduction Bicellular Tight Junction Establishment Of Epithelial Cell Polarity Adherens Junction Guanyl-nucleotide Exchange Factor Activity Regulation Of Small GTPase Mediated Signal Transduction Lipid Binding Anchoring Junction Establishment Of Cell Polarity Guanylate Kinase-associated Protein Clustering Embryonic Olfactory Bulb Interneuron Precursor Migration	GTPase Activity GTP Binding Endomembrane System Nucleotide Binding Vesicle-mediated Transport Positive Regulation Of Establishment Of Protein Localization Regulation Of Superoxide Anion Generation Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Metabolic Process Sarcomere Cellular Localization Protein Transport Intracellular Protein Transport Regulation Of Transport Membrane Invagination Mitotic Cleavage Furrow Ingression Regulation Of Vesicle-mediated Transport Presynaptic Endocytosis Regulation Of Establishment Of Protein Localization Positive Regulation Of Transport Regulation Of Cellular Localization Regulation Of Filopodium Assembly Synaptic Vesicle Endocytosis Regulation Of Dendritic Spine Development Erythrocyte Apoptotic Process Positive Regulation Of Protein Transport Fat Cell Apoptotic Process B Cell Proliferation Regulation Of Platelet Activation Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Glucosylceramide Catabolic Process Endosomal Transport Regulation Of Actin Filament Organization Intracellular Protein Localization Intracellular Transport GDP Binding Enzyme Activator Activity Regulation Of Biological Quality Cleavage Furrow Ingression Regulation Of Endocytosis Positive Regulation Of Secretion By Cell Protein Localization To Membrane G Protein Activity Lung Connective Tissue Development Alveolar Secondary Septum Development Regulation Of Body Fluid Levels Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Positive Regulation Of Reactive Oxygen Species Metabolic Process Integrin AlphaL-beta2 Complex