PRDX6 and ORM2

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		PRDX6	ORM2
Name		peroxiredoxin 6	orosomucoid 2
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Lysosome Cytosol Membrane Azurophil Granule Lumen Perinuclear Region Of Cytoplasm Extracellular Exosome	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen Azurophil Granule Lumen Specific Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	Catalytic Activity Peroxidase Activity Glutathione Peroxidase Activity Phospholipase A2 Activity Protein Binding Antioxidant Activity Oxidoreductase Activity Transferase Activity Hydrolase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Cadherin Binding 1-acylglycerophosphocholine O-acyltransferase Activity Calcium-independent Phospholipase A2 Activity Peroxiredoxin Activity	Protein Binding
	Biological Process	Lipid Metabolic Process Response To Oxidative Stress Lipid Catabolic Process Hydrogen Peroxide Catabolic Process Cell Redox Homeostasis Glycerophospholipid Catabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Cellular Oxidant Detoxification	Regulation Of Immune System Process Acute-phase Response Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Positive Regulation Of Tumor Necrosis Factor Production
Pathways		Detoxification of Reactive Oxygen Species Neutrophil degranulation	Platelet degranulation Neutrophil degranulation
Drugs		2-(N-morpholino)ethanesulfonic acid Copper	Disopyramide Lidocaine Imipramine Chlorpromazine Thalidomide Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
GWAS		Adult body size ( 32376654 ) Asthma (age of onset) ( 31036433 ) Asthma (childhood onset) ( 31036433 ) Blood protein levels ( 30072576 ) Systemic lupus erythematosus ( 26663301 ) Systemic sclerosis ( 31672989 )	No GWAS studies recorded
Interacting Genes		22 interacting genes: CASP10 CASP8 GPX4 GSTP1 HNF4G MAPK1 NCF2 NR4A1 ORM2 PAXIP1 PPARD PSMD8 RARA SEPHS2 SFTPA1 STH SUMO2 SUMO4 TERF1 TERF2IP UCHL5 YWHAE	3 interacting genes: CYP39A1 PRDX6 STK3
Entrez ID		9588	5005
HPRD ID		03817	00725
Ensembl ID		ENSG00000117592	ENSG00000228278
Uniprot IDs		P30041 V9HWC7	P19652
PDB IDs		1PRX 5B6M 5B6N	3APU 3APV 3APW 3APX 7OUB
GO Terms Enriched among Interactors		Response To Molecule Of Bacterial Origin Response To Lipopolysaccharide Nuclear Receptor Activity Positive Regulation Of Telomere Maintenance Death Effector Domain Binding Response To Stress Intracellular Receptor Signaling Pathway Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Response To Estradiol Ripoptosome Positive Regulation Of Metabolic Process Response To External Biotic Stimulus CD95 Death-inducing Signaling Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Shelterin Complex Positive Regulation Of DNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Response To Lipid Regulation Of Canonical NF-kappaB Signal Transduction Nuclear Telomere Cap Complex Nucleus G-rich Strand Telomeric DNA Binding Connective Tissue Development Telomere Capping Apoptotic Process Response To Vitamin Response To Vitamin A Programmed Cell Death Cell Death Protein Tag Activity Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Chromosome Organization Regulation Of Interleukin-1 Beta Production Telomere Maintenance Positive Regulation Of Execution Phase Of Apoptosis Glutathione Peroxidase Activity Face Development Telomere Maintenance Via Telomerase Regulation Of DNA Metabolic Process Regulation Of Interleukin-1 Production Execution Phase Of Apoptosis RNA-templated DNA Biosynthetic Process Response To Ethanol Ubiquitin-like Protein Ligase Binding Regulation Of RNA Metabolic Process Negative Regulation Of MiRNA Transcription Ubiquitin Protein Ligase Binding	Steroid 7-alpha-hydroxylase Activity Oxysterol 7-alpha-hydroxylase Activity 24S-hydroxycholesterol 7-alpha-hydroxylase Activity Primitive Hemopoiesis Neural Tube Formation Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Endocardium Development 1-acylglycerophosphocholine O-acyltransferase Activity Calcium-independent Phospholipase A2 Activity Peroxiredoxin Activity Lipid Catabolic Process Cholesterol Catabolic Process BBSome