APBA3 and TANK

Number of citations: 55 (PubMedID 21903422)
Data Source: BioGRID (pull down)

		APBA3	TANK
Name		amyloid beta precursor protein binding family A member 3	TRAF family member associated NFKB activator
Structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Dendritic Spine Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol Protein-containing Complex Serine/threonine Protein Kinase Complex
	Molecular Function	Amyloid-beta Binding Enzyme Inhibitor Activity Protein Binding Enzyme Binding	Cysteine-type Deubiquitinase Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Deubiquitinase Activator Activity Metal Ion Binding Molecular Adaptor Activity Molecular Function Inhibitor Activity
	Biological Process	In Utero Embryonic Development Chemical Synaptic Transmission Regulation Of Gene Expression Protein Transport Negative Regulation Of Catalytic Activity	DNA Damage Response Signal Transduction Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Negative Regulation Of Canonical NF-kappaB Signal Transduction Defense Response To Virus Type I Interferon-mediated Signaling Pathway Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Ionizing Radiation Positive Regulation Of Protein Deubiquitination Positive Regulation Of Ubiquitin-specific Protease Activity
Pathways		Neurexins and neuroligins	TICAM1-dependent activation of IRF3/IRF7 TRAF6 mediated IRF7 activation Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
GWAS		Serum alkaline phosphatase levels ( 33547301 )	Alcohol consumption ( 27911795 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Chronotype ( 30696823 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Dietary macronutrient intake ( 23372041 ) Educational attainment ( 25201988 ) Educational attainment (years of education) ( 23722424 ) Extremely high intelligence ( 29520040 ) General cognitive ability ( 29844566 ) Household income (MTAG) ( 31844048 ) Obesity-related traits ( 23251661 ) Presence of antiphospholipid antibodies ( 23509613 ) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482 ) Smoking status (ever vs never smokers) ( 30643258 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Subcutaneous adipose tissue ( 22589738 ) Tourette syndrome ( 30818990 ) Treatment response for severe sepsis ( 22310353 ) Weight ( 31647587 )
Interacting Genes		8 interacting genes: APP ARF3 ARF4 AZI2 BCR EGFR TANK TBKBP1	32 interacting genes: AIMP2 APBA3 APP ATP6V1H BIK CD40 CHUK COPB1 FBLN1 HLA-C IKBKB IKBKE IKBKG INPP5K KPNA2 LAMC1 MAP4K5 MARCHF5 RACGAP1 SDC4 SMAD3 SRSF11 TBK1 TP53BP2 TRAF1 TRAF2 TRAF3 TRAF6 TSC1 USP7 WEE2-AS1 ZC3H12A
Entrez ID		9546	10010
HPRD ID		05038	04870
Ensembl ID		ENSG00000011132	ENSG00000136560
Uniprot IDs		O96018	B2R7S3 Q6NW12 Q92844
PDB IDs		2YT7 2YT8 5UWS	1KZZ 1L0A 5H10
GO Terms Enriched among Interactors		Serine/threonine Protein Kinase Complex Type I Interferon-mediated Signaling Pathway Interferon-mediated Signaling Pathway Collateral Sprouting Response To External Biotic Stimulus Cell Surface Receptor Signaling Pathway Protein-containing Complex Regulation Of Reactive Oxygen Species Metabolic Process Dendritic Spine Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Synapse Organization Regulation Of Response To Calcium Ion Learning Or Memory Perinuclear Region Of Cytoplasm Amylin Binding Positive Regulation Of Toll Signaling Pathway Dendrite Development Signal Transduction Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Epidermal Growth Factor Receptor Signaling Pathway Multivesicular Body, Internal Vesicle Lumen Defense Response To Virus Positive Regulation Of Ubiquitin-specific Protease Activity Cognition Negative Regulation Of Signal Transduction Acetylcholine Receptor Activator Activity Developmental Growth Response To Interleukin-1 Plasma Membrane Bounded Cell Projection Organization Regulation Of MiRNA Transcription Negative Regulation Of Signaling Cellular Localization Lipoprotein Particle Regulation Of Programmed Cell Death Positive Regulation Of Protein Import Negative Regulation Of Cell Communication Nervous System Process ERBB Signaling Pathway Phospholipase D Activator Activity Negative Regulation Of Blood Vessel Remodeling Negative Regulation Of Neutrophil Degranulation Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Shc-EGFR Complex Regulation Of MiRNA Metabolic Process Negative Regulation Of Programmed Cell Death PTB Domain Binding Axon Collateral Sprouting In Absence Of Injury Regulation Of Protein Import	CD40 Receptor Complex Regulation Of Canonical NF-kappaB Signal Transduction Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Immune Response Regulation Of Cytokine Production Regulation Of DNA-binding Transcription Factor Activity Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Immune Response Response To Virus Intracellular Signaling Cassette Non-canonical NF-kappaB Signal Transduction Regulation Of Signal Transduction IkappaB Kinase Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Signal Transduction Positive Regulation Of Type I Interferon Production Positive Regulation Of Immune System Process Positive Regulation Of Cytokine Production Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Regulation Of Cell Communication Response To Other Organism Regulation Of Signaling Immune Response-regulating Signaling Pathway Cytoplasmic Side Of Plasma Membrane Positive Regulation Of DNA-binding Transcription Factor Activity Activation Of Immune Response Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Innate Immune Response Canonical NF-kappaB Signal Transduction Regulation Of Innate Immune Response Activation Of Innate Immune Response Immune Response Positive Regulation Of Defense Response Positive Regulation Of Gene Expression Regulation Of Type I Interferon Production IkappaB Kinase Complex Regulation Of Defense Response Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Tumor Necrosis Factor Receptor Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Response To External Biotic Stimulus Signaling Adaptor Activity Positive Regulation Of Signal Transduction Immune System Process Pattern Recognition Receptor Signaling Pathway CD40 Signaling Pathway