GOSR1 and STX5

Number of citations: 54 (PubMedID 12388752)
Data Source: HPRD (two hybrid, in vitro, in vivo)

		GOSR1	STX5
Name		golgi SNAP receptor complex member 1	syntaxin 5
Structure		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Golgi Medial Cisterna Cis-Golgi Network Cytosol Membrane Transport Vesicle SNARE Complex	Golgi Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Endomembrane System ER To Golgi Transport Vesicle Membrane Membrane SNARE Complex Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Bounding Membrane Of Organelle
	Molecular Function	SNAP Receptor Activity	SNARE Binding SNAP Receptor Activity Protein Binding Cadherin Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport Vesicle Fusion Protein Transport Vesicle-mediated Transport Retrograde Transport, Endosome To Golgi Inter-Golgi Cisterna Vesicle-mediated Transport	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Vesicle Fusion Vesicle-mediated Transport Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Positive Regulation Of Protein Catabolic Process Vesicle Docking Golgi Disassembly Regulation Of Golgi Organization
Pathways		COPI-mediated anterograde transport Intra-Golgi traffic	COPII-mediated vesicle transport Cargo concentration in the ER COPI-mediated anterograde transport Intra-Golgi traffic RHOA GTPase cycle RHOC GTPase cycle RHOG GTPase cycle Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
GWAS		No GWAS studies recorded	Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Interacting Genes		9 interacting genes: ACKR5 APP EBI3 GABARAPL2 NAPA NSF SNAP25 STX5 USO1	48 interacting genes: AARD APLP1 AQP6 BAG6 BET1 COPS6 CRB3 CREB3L3 DRC12 EBP FAM209A GOSR1 GOSR2 GPANK1 GPR152 HAP1 HSD17B13 IMMT JAGN1 KASH5 LMNA LNX1 LRIF1 LRRC4C MAGEA6 MTUS1 NAPA NAPB NSFL1C REEP4 RETREG3 SCFD1 SEC22B SNAP23 SNAP25 STING1 STX1A STX2 STX3 STX4 STXBP1 TACC1 TMEM31 TP53 USO1 VAPB VCP VCPIP1
Entrez ID		9527	6811
HPRD ID		04936	04426
Ensembl ID		ENSG00000108587	ENSG00000162236
Uniprot IDs		E9PCW1 O95249	B4DKR0 Q13190
PDB IDs		Not available	3EFO
GO Terms Enriched among Interactors		SNARE Binding Membrane Fusion Golgi Vesicle Transport Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport SNARE Complex Disassembly Vesicle Docking Membrane Organization Organelle Localization By Membrane Tethering Membrane Docking Vesicle Fusion Organelle Membrane Fusion Regulation Of Protein Catabolic Process Establishment Of Localization In Cell Syntaxin-1 Binding Organelle Fusion Synaptic Vesicle Priming Protein-containing Complex Disassembly Secretory Granule Localization Protein Transport Intracellular Protein Transport Positive Regulation Of Protein Catabolic Process Intracellular Transport SNAP Receptor Activity Golgi Stack Dendritic Shaft Establishment Of Protein Localization Golgi Apparatus SNARE Complex Syntaxin Binding Protein-containing Complex Organization Amyloid-beta Complex Growth Cone Lamellipodium Chemical Synaptic Transmission Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Localization Vesicle Organization ER To Golgi Transport Vesicle Membrane Golgi Vesicle Docking Trans-synaptic Signaling Synaptic Signaling Positive Regulation Of Type II Interferon Production Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Intracellular Protein Localization Interleukin-27 Receptor Binding Associative Learning	SNAP Receptor Activity Membrane Fusion Membrane Organization SNARE Complex Organelle Membrane Fusion Organelle Fusion Vesicle Fusion Establishment Of Localization In Cell Protein Transport Establishment Of Protein Localization SNARE Binding Vesicle-mediated Transport Intracellular Transport Cellular Localization Vesicle Organization Organelle Localization By Membrane Tethering Membrane Docking Organelle Localization Vesicle Docking Organelle Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Intracellular Protein Transport Intracellular Protein Localization Golgi Vesicle Transport Exocytosis Regulation Of Synaptic Vesicle Priming Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Synaptic Vesicle Priming Syntaxin Binding Endoplasmic Reticulum Endoplasmic Reticulum Organization Secretion By Cell Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Glutamatergic Synapse Positive Regulation Of Synaptic Transmission Vesicle Fusion To Plasma Membrane SNARE Complex Assembly Specific Granule VCP-NSFL1C Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Neurotransmitter Transport Synaptic Vesicle Membrane Organization Secretion Membrane Membrane Assembly Secretory Granule Localization Soluble NSF Attachment Protein Activity SNARE Complex Disassembly Endoplasmic Reticulum Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex