GAL3ST1 and ARSA

Number of citations: 0 (PubMedID 2562955)
Data Source: HPRD (in vitro)

		GAL3ST1	ARSA
Name		galactose-3-O-sulfotransferase 1	arylsulfatase A
Structure		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Plasma Membrane Membrane	Extracellular Region Lysosome Endoplasmic Reticulum Endoplasmic Reticulum Lumen Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome
	Molecular Function	Galactosylceramide Sulfotransferase Activity Sulfotransferase Activity Transferase Activity	Arylsulfatase Activity Cerebroside-sulfatase Activity Calcium Ion Binding Protein Binding Sulfuric Ester Hydrolase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Protein N-linked Glycosylation Lipid Metabolic Process Sphingolipid Metabolic Process Galactosylceramide Metabolic Process Galactosylceramide Biosynthetic Process Glycosphingolipid Biosynthetic Process Spermatogenesis Glycolipid Biosynthetic Process Myelination Glycerolipid Metabolic Process	Lipid Metabolic Process
Pathways		Glycosphingolipid biosynthesis	The activation of arylsulfatases Neutrophil degranulation Glycosphingolipid catabolism
Drugs		None	4-Nitrocatechol sulfate 2-Amino-3-Hydroxy-3-Phosphonooxy-Propionic Acid
Diseases		None	Metachromatic leukodystrophy (MLD)
GWAS		A body shape index ( 34021172 ) Brain morphology (MOSTest) ( 32665545 ) Creutzfeldt-Jakob disease (sporadic) ( 32949544 )	Aspartate aminotransferase levels ( 33547301 ) Fibrinogen ( 23969696 ) Fibrinogen levels ( 28107422 ) QT interval (ambient particulate matter interaction) ( 28749367 ) Urinary metabolite levels in chronic kidney disease ( 31959995 ) vWF and FVIII levels ( 30586737 )
Interacting Genes		2 interacting genes: APP ARSA	18 interacting genes: ANXA11 BMPR2 CAMK2B CCDC22 CETN2 CLEC4G CTSL EID2B FOXI1 GAL3ST1 PKN1 POU1F1 PPIC PROP1 RHOXF2 SNCA TRIP13 VENTX
Entrez ID		9514	410
HPRD ID		03806	09617
Ensembl ID		ENSG00000128242	ENSG00000100299
Uniprot IDs		B2R7S4 Q99999	A0A0C4DFZ2 B4DVI5 P15289
PDB IDs		Not available	1AUK 1E1Z 1E2S 1E33 1E3C 1N2K 1N2L 2AIJ 2AIK 2HI8
GO Terms Enriched among Interactors		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Endoplasmic Reticulum Lumen Cerebroside-sulfatase Activity Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Lysosome Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Sulfuric Ester Hydrolase Activity Arylsulfatase Activity Antifungal Humoral Response Nuclear Envelope Lumen Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding	None