ADAMTS2 and PIK3R1

Number of citations: 0 (PubMedID 18624398)
Data Source: BioGRID (two hybrid)

		ADAMTS2	PIK3R1
Name		ADAM metallopeptidase with thrombospondin type 1 motif 2	phosphoinositide-3-kinase regulatory subunit 1
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix	Nucleus Cytoplasm Cis-Golgi Network Cytosol Plasma Membrane Cell-cell Junction Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA Membrane Perinuclear Region Of Cytoplasm Perinuclear Endoplasmic Reticulum Membrane
	Molecular Function	Metalloendopeptidase Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Phosphotyrosine Residue Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity GTPase Activator Activity Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Neurotrophin TRKA Receptor Binding Protein Binding Kinase Regulator Activity Kinase Activator Activity Protein Phosphatase Binding Phosphatidylinositol 3-kinase Regulator Activity Phosphatidylinositol 3-kinase Regulatory Subunit Binding ErbB-3 Class Receptor Binding Phosphatidylinositol 3-kinase Binding Insulin Binding Insulin Receptor Substrate Binding 1-phosphatidylinositol-3-kinase Regulator Activity Protein Heterodimerization Activity Phosphatidylinositol Kinase Activity Enzyme-substrate Adaptor Activity Phosphatidylinositol 3-kinase Activator Activity
	Biological Process	Proteolysis Spermatogenesis Protein Processing Extracellular Matrix Organization Collagen Fibril Organization Lung Development Collagen Catabolic Process Skin Development	Intracellular Glucose Homeostasis Negative Regulation Of Cell-matrix Adhesion Positive Regulation Of Leukocyte Migration Transcription By RNA Polymerase II Protein Import Into Nucleus Immune Response Negative Regulation Of Cell Adhesion Signal Transduction Insulin Receptor Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Lamellipodium Assembly Protein Transport Cytokine-mediated Signaling Pathway B Cell Differentiation T Cell Differentiation Osteoclast Differentiation Positive Regulation Of Tumor Necrosis Factor Production Cellular Response To Insulin Stimulus Positive Regulation Of RNA Splicing Regulation Of Toll-like Receptor 4 Signaling Pathway Substrate Adhesion-dependent Cell Spreading Cellular Response To UV Response To Endoplasmic Reticulum Stress Interleukin-18-mediated Signaling Pathway Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of D-glucose Import Phosphatidylinositol Phosphate Biosynthetic Process Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Protein Stabilization Positive Regulation Of Filopodium Assembly Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Growth Hormone Receptor Signaling Pathway T Follicular Helper Cell Differentiation Myeloid Leukocyte Migration Positive Regulation Of Focal Adhesion Disassembly Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Plasma Membrane
Pathways		Collagen biosynthesis and modifying enzymes Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins	PI3K Cascade IRS-mediated signalling GPVI-mediated activation cascade Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants PI3K events in ERBB4 signaling PIP3 activates AKT signaling Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Synthesis of PIPs at the plasma membrane GAB1 signalosome Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction PI3K events in ERBB2 signaling PI3K/AKT activation Signaling by ALK Downstream TCR signaling Role of phospholipids in phagocytosis Tie2 Signaling Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling Role of LAT2/NTAL/LAB on calcium mobilization Nephrin family interactions CD28 dependent PI3K/Akt signaling G alpha (q) signalling events GP1b-IX-V activation signalling VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling Constitutive Signaling by EGFRvIII PI-3K cascade:FGFR1 PI-3K cascade:FGFR2 PI-3K cascade:FGFR3 PI-3K cascade:FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease Signaling by FGFR3 in disease RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates PI3K/AKT signaling RET signaling RHOA GTPase cycle Extra-nuclear estrogen signaling RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Activated NTRK2 signals through PI3K RHOF GTPase cycle Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Activated NTRK3 signals through PI3K FLT3 Signaling FLT3 Signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Signaling by CSF1 (M-CSF) in myeloid cells RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle Signaling by FLT3 fusion proteins Signaling by FLT3 fusion proteins Signaling by FLT3 ITD and TKD mutants Signaling by FLT3 ITD and TKD mutants Signaling by ALK fusions and activated point mutants Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Signaling by LTK in cancer Signaling by LTK Co-stimulation by ICOS
Drugs		None	SF1126 Enzastaurin Wortmannin
Diseases		Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)	None
GWAS		Attention deficit hyperactivity disorder (time to onset) ( 18937294 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Central corneal thickness ( 29760442 ) Depression in response to interferon-based therapy in chronic hepatitis C ( 27723809 ) Height ( 25282103 ) Intake of total sugars ( 31005972 ) Intraocular pressure ( 29617998 31798171 ) Intraocular pressure and central corneal thickness (multi-trait analysis) ( 31798171 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Refractive astigmatism ( 30306274 ) Schizophrenia, bipolar disorder or major depressive disorder ( 34099189 ) Stroke (pediatric) ( 22990015 ) Visceral adipose tissue adjusted for BMI ( 22589738 ) Waist circumference adjusted for body mass index ( 34021172 )	Alzheimer's disease biomarkers ( 23419831 ) Anthropometric traits (multi-trait analysis) ( 30166351 ) Appendicular lean mass ( 33097823 ) Basal cell carcinoma ( 33549134 ) Birth weight ( 31043758 ) Body fat percentage and HDL-C (pairwise) ( 33619380 ) Bone mineral density (hip) ( 26911590 ) Corneal astigmatism ( 30306274 ) Crohn's disease ( 32581322 ) Estimated glomerular filtration rate ( 30604766 31152163 ) Glomerular filtration rate (creatinine) ( 28452372 26831199 ) HDL cholesterol levels ( 32203549 ) Height ( 31562340 ) Hip minimal joint space width ( 27701424 ) Intelligence (MTAG) ( 29326435 ) Leg fat mass (lean adjusted) ( 32719433 ) Leg fat mass and leg lean mass (pleiotropy) ( 32719433 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular volume ( 32888494 27863252 ) Mean reticulocyte volume ( 32888494 ) Menarche (age at onset) ( 23599027 ) Offspring birth weight ( 31043758 ) Red cell distribution width ( 32888494 27863252 ) Rosacea symptom severity ( 29771307 ) Triglyceride levels ( 32203549 29083408 ) Type 2 diabetes (adjusted for BMI) ( 30297969 ) Waist circumference adjusted for body mass index ( 34021172 )
Interacting Genes		1 interacting genes: PIK3R1	180 interacting genes: ABL1 ADAM12 ADAMTS2 AGAP2 AKT1 ALK ANK3 APPL1 AR ARAF ARHGAP1 ARHGAP17 ARHGAP32 AXL BCAR1 BLK BRCA1 CBL CBLB CCL14 CD19 CD22 CD28 CD2AP CD3E CD4 CD40 CD5 CD7 CDC42 CDH2 CHRNA7 CIP2A CLNK CRK CRKL CSF1R CSF2RA CTLA4 CTNNB1 CXCL2 CYP4A11 DLX2 DNM1 DOK1 EGF EGFR ENKUR EPHA2 EPOR ERAS ERBB2 ERBB3 ERBB4 ESR1 EZR FASLG FBXO21 FCGR2A FER FES FGFR1 FLT1 FYN GAB1 GAB2 GAB3 GHR GP1BA GRB2 GSPT1 GTF2H1 HCK HCST HGS HOXA1 HRAS HTT IFNAR1 IGF1R IKZF3 IL13 IL1R1 IL1RAP IL2RB IL7R INPP4A INSR IRS1 IRS2 IRS4 ITSN1 JAK1 JAK2 JAK3 KBTBD2 KHDRBS1 KIT LAT LCK LNX2 LRRK2 MAPK8 MAPT MET MME MST1R MYO16 NFKBIA NLRP6 NTRK1 NTRK2 NUP85 NYAP1 NYAP2 PASK PDE4D PDGFB PDGFRA PDGFRB PECAM1 PFN1 PIK3AP1 PIK3CA PIK3CB PIK3CD PPM1A PRMT8 PROM1 PSEN1 PSMB5 PTEN PTK2 PTK2B PTPN11 PTPN6 RAC1 RASA1 RASD2 RB1 RET RRAS2 SH3KBP1 SHB SHC1 SLC9A2 SOCS1 SOCS6 SOCS7 SQSTM1 SRC SSTR2 STAT3 SYK SYN1 TEC TEK TGFBR1 TGFBR2 TIE1 TLR2 TNK2 TNS4 TOM1L1 TRAT1 TRIM25 TSHR TTR TUB TUBA1B TUBG1 TXK TYK2 TYRO3 VAV1 VAV3 WAS WASF3 WBP11 YWHAG
Entrez ID		9509	5295
HPRD ID		05173	01381
Ensembl ID		ENSG00000087116	ENSG00000145675
Uniprot IDs		O95450	A0A2X0SFG1 P27986
PDB IDs		Not available	1A0N 1AZG 1H9O 1PBW 1PHT 1PIC 1PKS 1PKT 2IUG 2IUH 2IUI 2RD0 2V1Y 3HHM 3HIZ 3I5R 3I5S 4A55 4JPS 4L1B 4L23 4L2Y 4OVU 4OVV 4WAF 4YKN 4ZOP 5AUL 5FI4 5GJI 5ITD 5M6U 5SW8 5SWG 5SWO 5SWP 5SWR 5SWT 5SX8 5SX9 5SXA 5SXB 5SXC 5SXD 5SXE 5SXF 5SXI 5SXJ 5SXK 5UBT 5UK8 5UKJ 5UL1 5VLR 5XGH 5XGI 5XGJ 6NCT 6PYR 6PYU 7CIO 7LM2 7LQ1 7MYN 7MYO 7PG5 7PG6 7RNS 7TZ7 8AM0 8DCP 8DCX 8DD4 8DD8 8GUB 8H36 8H37 8ILR 8ILS 8ILV 8SBC 8SBJ 8TDU 8TGD 8TS7 8TS8 8TS9 8TSA 8TSB 8TSC 8TSD 8TU6 8V8H 8V8I 8V8J 8V8U 8V8V 8W9A 8W9B
GO Terms Enriched among Interactors		Kinase Regulator Activity Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Activator Activity Phosphatidylinositol 3-kinase Complex, Class IA Insulin Binding Perinuclear Endoplasmic Reticulum Membrane 1-phosphatidylinositol-3-kinase Regulator Activity Phosphatidylinositol Kinase Activity Positive Regulation Of Focal Adhesion Disassembly Neurotrophin TRKA Receptor Binding Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Phosphatidylinositol 3-kinase Regulator Activity T Follicular Helper Cell Differentiation ErbB-3 Class Receptor Binding Kinase Activator Activity Insulin Receptor Substrate Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding Interleukin-18-mediated Signaling Pathway Enzyme-substrate Adaptor Activity Insulin-like Growth Factor Receptor Binding Phosphatidylinositol 3-kinase Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors T-helper Cell Differentiation Regulation Of Toll-like Receptor 4 Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Stress Fiber Assembly Insulin Receptor Binding Growth Hormone Receptor Signaling Pathway Negative Regulation Of Osteoclast Differentiation Phosphotyrosine Residue Binding Positive Regulation Of Lamellipodium Assembly Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Cell-matrix Adhesion Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of D-glucose Import Regulation Of Lamellipodium Assembly Positive Regulation Of D-glucose Transmembrane Transport Osteoclast Differentiation Substrate Adhesion-dependent Cell Spreading T Cell Differentiation Involved In Immune Response Positive Regulation Of RNA Splicing Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Filopodium Assembly Positive Regulation Of Lamellipodium Organization Natural Killer Cell Mediated Immunity Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Protein Import Into Nucleus Regulation Of Filopodium Assembly Cis-Golgi Network	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Protein Tyrosine Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Plasma Membrane Regulation Of Signal Transduction Regulation Of Cell Communication Intracellular Signal Transduction Regulation Of Signaling Regulation Of Multicellular Organismal Process Regulation Of Immune System Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Peptidyl-tyrosine Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune System Process Immune System Process Protein Kinase Activity Regulation Of Immune Response Kinase Activity Positive Regulation Of Multicellular Organismal Process Transmembrane Receptor Protein Tyrosine Kinase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Phosphorylation Immune Response-regulating Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Cell Population Proliferation Protein Phosphorylation Receptor Complex Positive Regulation Of MAPK Cascade Intracellular Signaling Cassette Regulation Of Cell Population Proliferation Regulation Of Cell Activation Antigen Receptor-mediated Signaling Pathway Immune Response-activating Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Immune Response Cell Migration Cytokine-mediated Signaling Pathway Protein Autophosphorylation Regulation Of Developmental Process Regulation Of Lymphocyte Activation Positive Regulation Of Cell Migration Activation Of Immune Response