ARHGEF6 and PARVB

Number of citations: 0 (PubMedID 12499396)
Data Source: HPRD (two hybrid, in vitro)

		ARHGEF6	PARVB
Name		Rac/Cdc42 guanine nucleotide exchange factor 6	parvin beta
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cell-cell Junction Lamellipodium Cell Projection	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Sarcomere Z Disc Lamellipodium Cell Projection Anchoring Junction
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	Actin Binding Protein Binding
	Biological Process	Apoptotic Process JNK Cascade Lamellipodium Assembly	Cell Adhesion Cell Projection Assembly Lamellipodium Assembly Actin Cytoskeleton Organization Substrate Adhesion-dependent Cell Spreading Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Plasma Membrane Bounded Cell Projection Assembly
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events Regulation of cytoskeletal remodeling and cell spreading by IPP complex components G beta:gamma signalling through CDC42 CDC42 GTPase cycle RAC1 GTPase cycle RHOU GTPase cycle	Cell-extracellular matrix interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Diseases		Non-syndromic X-linked mental retardation	None
GWAS		Autism spectrum disorder ( 34069769 ) Breast cancer ( 29059683 )	Alzheimer's disease (cognitive decline) ( 23535033 ) Hematological and biochemical traits ( 20139978 ) Lewy body disease ( 25188341 ) Monocyte count ( 32888494 ) Nonalcoholic fatty liver disease ( 22719876 ) Pediatric non-alcoholic fatty liver disease activity score ( 23535911 ) Response to chemotherapy in breast cancer (hypertension) (bevacizumab) ( 25117820 ) Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) ( 25117820 ) Systemic sclerosis (anti-centromere-positive) ( 29293537 )
Interacting Genes		36 interacting genes: ADAM15 ARAP3 ARHGEF7 BMPR1B CAPNS1 CBFA2T3 CCDC33 CDC42 EPHB2 GIT1 GOLGA2 GPRASP2 HSF2BP KRT27 NUTM1 PAK1 PAK2 PAK3 PARVB PNMA1 POU6F2 RWDD2A SH2D1A SH3GL3 SIRPA SMAD1 SMAD2 SMAD3 TGFBR1 TGFBR2 TMEM108 TP53BP2 TRAF2 TRIM54 YWHAG ZNF580	3 interacting genes: ARHGEF6 ILK PCNT
Entrez ID		9459	29780
HPRD ID		02226	16284
Ensembl ID		ENSG00000129675	ENSG00000188677
Uniprot IDs		B7Z3C7 Q15052 Q8N4Q3	A0A087WZB5 Q9HBI1
PDB IDs		1UJY 1WYR	4EDL 4EDM 4EDN
GO Terms Enriched among Interactors		Enzyme-linked Receptor Protein Signaling Pathway Response To Growth Factor Dendritic Spine Development I-SMAD Binding Cellular Response To Growth Factor Stimulus Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Ephrin Receptor Signaling Pathway SMAD Protein Signal Transduction SMAD Protein Complex Trophoblast Cell Migration Heteromeric SMAD Protein Complex Embryonic Cranial Skeleton Morphogenesis Activin Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity Regulation Of Stress Fiber Assembly Co-SMAD Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Primary MiRNA Processing Transforming Growth Factor Beta Receptor Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Binding Protein Kinase Binding Homomeric SMAD Protein Complex Positive Regulation Of Stress Fiber Assembly Regulation Of Actin Cytoskeleton Organization Dendritic Spine Morphogenesis Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Microtubule Nucleation Protein Kinase Activity Positive Regulation Of Actin Filament Bundle Assembly Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Paraxial Mesoderm Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex Regulation Of Actin Filament-based Process Response To Transforming Growth Factor Beta Immune System Process Regulation Of Cartilage Development Protein Serine/threonine Kinase Activity Regulation Of Cellular Component Organization Positive Regulation Of Cell Migration Regulation Of Actin Filament Organization Response To Cholesterol Roof Of Mouth Development Response To Stress Positive Regulation Of Cell Motility Regulation Of Organelle Organization Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation	Spindle Organization Mitotic Spindle Organization Cell Projection Organization Microtubule Cytoskeleton Organization Involved In Mitosis Lamellipodium Protein Localization To Cell Cortex Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Plasma Membrane Raft Assembly Schwann Cell Development Microtubule Cytoskeleton Organization Membrane Raft Assembly Plasma Membrane Raft Organization Caveola Assembly Cellular Component Assembly Fibroblast Migration Myelination In Peripheral Nervous System Centrosome Membrane Raft Organization Negative Regulation Of Neural Precursor Cell Proliferation Microtubule Nucleation Branching Involved In Ureteric Bud Morphogenesis Regulation Of Substrate Adhesion-dependent Cell Spreading Membrane Assembly Tumor Necrosis Factor-mediated Signaling Pathway Nerve Development Intracellular Signaling Cassette Cytoskeleton Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Platelet Aggregation Outflow Tract Morphogenesis Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Sarcomere Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Substrate Adhesion-dependent Cell Spreading Microtubule-based Process Positive Regulation Of BMP Signaling Pathway Plasma Membrane Bounded Cell Projection Organization Lamellipodium Assembly Lamellipodium Organization JNK Cascade Glial Cell Development Homotypic Cell-cell Adhesion