HOMER1 and C1orf116

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid, two hybrid), HPRD (two hybrid)

		HOMER1	C1orf116
Name		homer scaffold protein 1	chromosome 1 open reading frame 116
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Membrane Z Disc Axon Dendrite Cell Projection Neuron Projection Costamere Dendritic Spine Neuron Spine Apical Part Of Cell Synapse Postsynapse Glutamatergic Synapse Postsynaptic Cytosol	Cytoplasm Cytosol Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding G Protein-coupled Glutamate Receptor Binding Signaling Adaptor Activity Transmembrane Transporter Binding	Protein Binding
	Biological Process	Skeletal Muscle Contraction Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Positive Regulation Of Signal Transduction Behavioral Response To Cocaine Skeletal Muscle Fiber Development Protein Tetramerization Response To Calcium Ion Positive Regulation Of Calcium Ion Transport Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Calcium Ion Import Regulation Of Dendritic Spine Maintenance Regulation Of Store-operated Calcium Entry	None
Pathways		Neurexins and neuroligins Neurexins and neuroligins	None
GWAS		Bipolar disorder ( 31043756 34002096 ) Blood and toenail selenium levels ( 25343990 ) Cryptococcosis in HIV infection ( 33269293 ) Height ( 18193045 ) Hepcidin/ferritin ratio ( 27846281 ) Lateral ventricle temporal horn volume ( 31530798 ) Major depressive disorder ( 20673876 ) Metabolite levels ( 23823483 ) Toenail selenium levels ( 25343990 )	No GWAS studies recorded
Interacting Genes		31 interacting genes: ABI1 ABI3 AGAP2 AIMP1 BRME1 C1orf116 DBNL DNM3 EFNB2 FAM9A FAT1 FCHSD2 GRIA1 GRIK1 GRM1 GRM5 HOMER3 ITPR1 PATJ PIAS2 RAD54L2 RASAL3 RYR1 RYR2 SHANK1 SHANK2 STX12 SYCE2 TANC1 TRPC1 ZMYM5	3 interacting genes: APP HOMER1 HOMER3
Entrez ID		9456	79098
HPRD ID		09211	15294
Ensembl ID		ENSG00000152413	ENSG00000182795
Uniprot IDs		Q5U5K4 Q86YM7	Q9BW04
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Postsynaptic Density Glutamate Receptor Signaling Pathway Regulation Of Cytosolic Calcium Ion Concentration Cell Junction Organization Glutamatergic Synapse Dendritic Spine Monoatomic Ion Channel Activity Synapse Synapse Organization Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Intracellularly Gated Calcium Channel Activity Schaffer Collateral - CA1 Synapse Ligand-gated Ion Channel Signaling Pathway Intracellular Calcium Ion Homeostasis Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Postsynaptic Density Membrane Dendrite Neuron Projection Calcium Ion Homeostasis Postsynaptic Membrane Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration G Protein-coupled Glutamate Receptor Signaling Pathway Cell-cell Signaling Learning Regulation Of Synaptic Transmission, Glutamatergic G Protein-coupled Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential Ryanodine-sensitive Calcium-release Channel Activity Signaling Calcium-mediated Signaling Cell Communication Calcium Channel Activity Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission Associative Learning Synapse Assembly Regulation Of Postsynaptic Membrane Potential Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Calcium-induced Calcium Release Activity Dendritic Shaft Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Inorganic Ion Homeostasis Actin-based Cell Projection Regulation Of Sequestering Of Calcium Ion Cell Junction Assembly Glutamate-gated Calcium Ion Channel Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum	Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Binding Regulation Of Dendritic Spine Maintenance Regulation Of Store-operated Calcium Entry Regulation Of Calcium Ion Transport G Protein-coupled Glutamate Receptor Signaling Pathway Regulation Of Metal Ion Transport Regulation Of Monoatomic Ion Transport Modulation Of Chemical Synaptic Transmission Dendrite Regulation Of Synaptic Transmission, Glutamatergic Protein Tetramerization G Protein-coupled Receptor Signaling Pathway Regulation Of Calcium-mediated Signaling Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Synapse Regulation Of Postsynapse Organization Adult Behavior Dendritic Spine Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Postsynapse Protein Complex Oligomerization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Postsynaptic Density Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Transport Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway