CNOT8 and BTG2

Number of citations: 0 (PubMedID 11136725)
Data Source: HPRD (in vitro, in vivo)

		CNOT8	BTG2
Name		CCR4-NOT transcription complex subunit 8	BTG anti-proliferation factor 2
Structure		No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol CCR4-NOT Complex CCR4-NOT Core Complex	Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	3'-5'-RNA Exonuclease Activity Nucleic Acid Binding RNA Binding Nuclease Activity Exonuclease Activity Poly(A)-specific Ribonuclease Activity Protein Binding Hydrolase Activity Metal Ion Binding	Transcription Corepressor Activity Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of Translation Positive Regulation Of Cell Population Proliferation Regulatory NcRNA-mediated Gene Silencing MiRNA-mediated Gene Silencing By MRNA Destabilization Positive Regulation Of MRNA Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair DNA Damage Response Neuroblast Proliferation Negative Regulation Of Neuroblast Proliferation Negative Regulation Of Cell Population Proliferation Associative Learning Response To Mechanical Stimulus Anterior/posterior Pattern Specification Negative Regulation Of Translation Dentate Gyrus Development Central Nervous System Neuron Development Neuron Differentiation Neuron Projection Development Skeletal Muscle Cell Differentiation Negative Regulation Of Apoptotic Process Response To Peptide Hormone Negative Regulation Of Neuron Apoptotic Process Response To Electrical Stimulus Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Neural Precursor Cell Proliferation Cellular Response To Phorbol 13-acetate 12-myristate
Pathways		Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain M-decay: degradation of maternal mRNAs by maternally stored factors	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
GWAS		High light scatter reticulocyte count ( 32888494 )	Immature fraction of reticulocytes ( 27863252 32888494 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular volume ( 27863252 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Red blood cell count ( 27863252 32888494 ) Red cell distribution width ( 27863252 28957414 32888494 )
Interacting Genes		11 interacting genes: BTG1 BTG2 BTG3 CNOT1 CNOT2 CNOT3 CNOT4 CNOT6 CRYAA PRMT1 TOB2	16 interacting genes: CCNB1 CDK1 CNOT7 CNOT8 HOXB9 HOXC8 MAPK14 MAPK3 PICK1 PIN1 PRKCA PRMT1 SKP2 SMAD1 SMAD9 SRA1
Entrez ID		9337	7832
HPRD ID		07225	03357
Ensembl ID		ENSG00000155508	ENSG00000159388
Uniprot IDs		B7Z9U0 E5RHL9 Q9UFF9	P78543
PDB IDs		Not available	3DJU 3E9V
GO Terms Enriched among Interactors		CCR4-NOT Complex Nuclear-transcribed MRNA Poly(A) Tail Shortening CCR4-NOT Core Complex Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly MRNA Catabolic Process Negative Regulation Of Gene Expression Poly(A)-specific Ribonuclease Activity Regulation Of Translation RNA Catabolic Process Trophectodermal Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Nucleobase-containing Compound Catabolic Process Negative Regulation Of Metabolic Process Regulatory NcRNA-mediated Gene Silencing Regulation Of Stem Cell Population Maintenance Regulation Of Developmental Process Nucleus Regulation Of Gene Expression MRNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening P-body Positive Regulation Of Organelle Assembly Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of MRNA Catabolic Process Cytoplasm Nucleic Acid Metabolic Process Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Translation Regulation Of RNA Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Megakaryocyte Differentiation Regulation Of Intracellular Estrogen Receptor Signaling Pathway Macromolecule Catabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Myeloid Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Organelle Assembly GATOR1 Complex Binding	Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cell Population Proliferation Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Cyclin B1-CDK1 Complex Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Positive Regulation Of RNA Metabolic Process Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Transcription By RNA Polymerase II Response To Stress Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Nucleoplasm Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Positive Regulation Of Heart Growth Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Metabolic Process Intracellular Signaling Cassette Positive Regulation Of Organ Growth Regulation Of MRNA Metabolic Process CCR4-NOT Core Complex G2/M Transition Of Mitotic Cell Cycle Mitogen-activated Protein Kinase P38 Binding SMAD Protein Complex Nucleus Cytosol Cell Cycle G2/M Phase Transition Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Heteromeric SMAD Protein Complex Regulation Of MRNA Stability Response To Mechanical Stimulus Regulation Of Heart Growth Ventricular Cardiac Muscle Cell Development Nucleic Acid Metabolic Process Regulation Of RNA Stability Mitotic Nuclear Membrane Disassembly Poly(A)-specific Ribonuclease Activity G1/S Transition Of Mitotic Cell Cycle