PIGM and PIGX

Number of citations: 36 (PubMedID 15635094)
Data Source: HPRD (in vitro, in vivo)

		PIGM	PIGX
Name		phosphatidylinositol glycan anchor biosynthesis class M	phosphatidylinositol glycan anchor biosynthesis class X
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Glycosylphosphatidylinositol-mannosyltransferase I Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Mannosyltransferase Activity GPI Mannosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Alpha-1,4-mannosyltransferase Activity Dol-P-Man:GlcN-acyl-PI Alpha-1,4-mannosyltransferase Activity	None
	Biological Process	GPI Anchor Biosynthetic Process	GPI Anchor Biosynthetic Process
Pathways		Synthesis of glycosylphosphatidylinositol (GPI)	Synthesis of glycosylphosphatidylinositol (GPI)
Diseases		Glycosylphosphatidylinositol (GPI) deficiency	None
GWAS		Bipolar disorder ( 31043756 )	Asthma ( 31959851 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Metabolite levels ( 23823483 )
Interacting Genes		3 interacting genes: CHEK1 LTB4R2 PIGX	1 interacting genes: PIGM
Entrez ID		93183	54965
HPRD ID		15133	07921
Ensembl ID		ENSG00000143315	ENSG00000163964
Uniprot IDs		Q9H3S5	Q8TBF5
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Negative Regulation Of G0 To G1 Transition Histone H3T11 Kinase Activity Regulation Of Mitotic Centrosome Separation Leukotriene Signaling Pathway Keratinocyte Migration Leukotriene B4 Receptor Activity Leukotriene Receptor Activity Mitotic Nuclear Membrane Disassembly Negative Regulation Of Adenylate Cyclase Activity Membrane Disassembly Nuclear Membrane Disassembly Inner Cell Mass Cell Proliferation Replicative Senescence Replication Fork Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Peptidyl-threonine Phosphorylation Nuclear Envelope Organization GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Apoptotic Process Involved In Development Positive Regulation Of Cell Cycle G2/M Phase Transition Mitotic G2 DNA Damage Checkpoint Signaling Epithelial Cell Migration	ABC-type Putrescine Transporter Activity Dol-P-Man:GlcN-acyl-PI Alpha-1,4-mannosyltransferase Activity Glycosylphosphatidylinositol-mannosyltransferase I Complex Alpha-1,4-mannosyltransferase Activity Polyamine Transmembrane Transporter Activity P-type Transmembrane Transporter Activity GPI Mannosyltransferase Activity P-type Ion Transporter Activity Putrescine Transport Polyamine Transmembrane Transport Mannosyltransferase Activity ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Glycolipid Biosynthetic Process Organic Cation Transport Glycolipid Metabolic Process Recycling Endosome Membrane Phosphatidylinositol Biosynthetic Process