SHKBP1 and CCNG1

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		SHKBP1	CCNG1
Name		SH3KBP1 binding protein 1	cyclin G1
Structure			No pdb structure
GO Annotations	Cellular Component	Lysosome	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
	Biological Process	Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein Homooligomerization	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Cell Division
Pathways		CDC42 GTPase cycle	Regulation of TP53 Degradation
GWAS		Carotid intima media thickness (mean) ( 31801372 ) Cleft lip with or without cleft palate x maternal periconceptional smoking interaction (parent of origin effect) ( 31372216 ) Hemoglobin levels ( 32327693 )	Aortic vascular smooth muscle cell proliferation in response to IL-1 beta ( 33040646 ) HIV progression (CD4 and viral load) ( 28132517 ) Metabolite levels ( 31628463 ) Plasma anti-thyroglobulin levels ( 29678681 ) Severe influenza A (H1N1) infection ( 26379185 )
Interacting Genes		14 interacting genes: CCNG1 COL7A1 CUL3 GRB2 HSP90AA1 HSP90AB1 LXN NR3C1 PIN1 PRPF3 SH3KBP1 UBC WEE2-AS1 YWHAG	28 interacting genes: APP CBY2 CCDC125 CDK5 CDKN2A DRC4 GAK GRN HMBOX1 KRT40 KRTAP10-7 LMNA LTBP3 LZTS2 MDM2 MT-CO2 NFATC4 PAK5 PLEKHA4 PNMA1 PPP2CA PTPA RBPMS SHKBP1 TFAP2C TFIP11 TNIP1 TP53
Entrez ID		92799	900
HPRD ID		15338	03345
Ensembl ID		ENSG00000160410	ENSG00000113328
Uniprot IDs		Q8TBC3	P51959
PDB IDs		4CRH	Not available
GO Terms Enriched among Interactors		Regulation Of Protein Modification Process Regulation Of Protein Stability Ubiquitin Protein Ligase Binding Tau Protein Binding Telomerase Holoenzyme Complex Assembly Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone TPR Domain Binding Protein-RNA Complex Assembly Protein Stabilization RNA Binding Chaperone-mediated Protein Complex Assembly Telomere Maintenance Via Telomerase DNA Polymerase Binding Axonal Growth Cone RNA-templated DNA Biosynthetic Process MHC Class II Protein Complex Binding Disordered Domain Specific Binding Identical Protein Binding Response To Temperature Stimulus Telomere Maintenance Via Telomere Lengthening Protein-containing Complex Assembly Protein Folding Chaperone Complex COP9 Signalosome Regulation Of Biological Quality ATP-dependent Protein Folding Chaperone Endodermal Cell Differentiation Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Protein Ubiquitination Positive Regulation Of Nitric Oxide Metabolic Process Protein-containing Complex Organization Supramolecular Fiber Organization Regulation Of Protein Metabolic Process Collagen Type VII Trimer Guanyl-nucleotide Exchange Factor Adaptor Activity Nuclear Glucocorticoid Receptor Activity CTP Binding DATP Binding Cellular Response To Heat Cis-trans Isomerase Activity Cellular Response To Stress Regulation Of Post-translational Protein Modification Protein Folding Chaperone Nucleoplasm Response To Stress Response To Hormone Regulation Of Nitric Oxide Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation	Positive Regulation Of Neuron Apoptotic Process Acetylcholine Receptor Activator Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Identical Protein Binding P53 Binding Disordered Domain Specific Binding Cellular Response To Actinomycin D Amyloid Fibril Formation Astrocyte Activation Involved In Immune Response Response To Actinomycin D Cellular Response To UV-C Regulation Of Proteolysis Regulation Of Protein Export From Nucleus Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Apoptotic Signaling Pathway Regulation Of Growth Negative Regulation Of Signal Transduction Regulation Of Neuron Apoptotic Process Negative Regulation Of Multicellular Organismal Process Organelle Organization Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Signal Transduction Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Proteolysis Regulation Of Protein Localization To Nucleus Negative Regulation Of Cellular Component Organization Cellular Response To Antibiotic Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Wnt Signaling Pathway Response To Light Stimulus Negative Regulation Of Wnt Signaling Pathway Regulation Of Carbohydrate Catabolic Process MDM2/MDM4 Family Protein Binding Cellular Senescence Regulation Of Cell Population Proliferation Regulation Of Cellular Response To Stress Negative Regulation Of Cell Projection Organization Protein Localization To Nucleus Regulation Of Cell Cycle G1/S Phase Transition Response To UV-C Regulation Of Cellular Component Organization Regulation Of MiRNA Transcription Replicative Senescence Regulation Of Protein Stability