CD8B and ST3GAL4

Number of citations: 0 (PubMedID 12459555)
Data Source: HPRD (in vitro)

		CD8B	ST3GAL4
Name		CD8 subunit beta	ST3 beta-galactoside alpha-2,3-sialyltransferase 4
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Cell Surface Membrane Early Endosome Membrane T Cell Receptor Complex Receptor Complex	Golgi Membrane Extracellular Region Golgi Apparatus Membrane Golgi Cisterna Membrane
	Molecular Function	Protein Binding Coreceptor Activity MHC Class I Protein Binding	Beta-galactoside (CMP) Alpha-2,3-sialyltransferase Activity N-acetyllactosaminide Alpha-2,3-sialyltransferase Activity Sialyltransferase Activity Transferase Activity Glycosyltransferase Activity Beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide Alpha-2,3- Sialyltransferase
	Biological Process	Adaptive Immune Response Immune System Process Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Activation Regulation Of Immune Response T Cell Receptor Signaling Pathway	Protein Glycosylation Lipid Metabolic Process Glycoprotein Biosynthetic Process Glycolipid Biosynthetic Process Oligosaccharide Biosynthetic Process Protein O-linked Glycosylation Via N-acetyl-galactosamine Keratan Sulfate Proteoglycan Biosynthetic Process Viral Protein Processing Positive Regulation Of Blood Coagulation Cognition Sialylation Positive Regulation Of Leukocyte Tethering Or Rolling
Pathways		Nef Mediated CD8 Down-regulation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Pre-NOTCH Processing in Golgi Keratan sulfate biosynthesis Sialic acid metabolism Lewis blood group biosynthesis Maturation of protein 3a Maturation of spike protein Maturation of protein 3a N-Glycan antennae elongation Termination of O-glycan biosynthesis
GWAS		Progressive supranuclear palsy ( 21685912 )	Apolipoprotein A1 levels ( 32203549 ) Apolipoprotein B levels ( 32203549 ) Aspartate aminotransferase levels ( 33547301 ) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809 ) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809 ) Cholesterol, total ( 20686565 24097068 25961943 ) Coronary artery disease ( 29212778 ) Factor VIII levels ( 30586737 ) HDL cholesterol levels ( 32203549 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Height ( 31562340 ) High light scatter reticulocyte count ( 32888494 ) LDL cholesterol ( 25961943 24097068 30275531 20686565 ) LDL cholesterol levels ( 32203549 28334899 30698716 ) LDL cholesterol levels in current drinkers ( 30698716 ) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 22001757 ) Low density lipoprotein cholesterol levels ( 33339817 32154731 ) Mean platelet volume ( 27863252 32888494 ) Medication use (HMG CoA reductase inhibitors) ( 31015401 ) Metabolite levels ( 23823483 ) Monocyte count ( 32888494 ) Mumps ( 28928442 ) N-glycan levels ( 31163085 ) Platelet count ( 27863252 32888494 ) Platelet distribution width ( 27863252 32888494 ) Plateletcrit ( 32888494 ) Refractive error ( 32231278 ) Serum alkaline phosphatase levels ( 31666285 33547301 29403010 33339817 ) Soluble E-selectin levels ( 31217265 ) Total cholesterol levels ( 33339817 28334899 30275531 ) vWF levels ( 30586737 )
Interacting Genes		3 interacting genes: CD3D CD8A ST3GAL4	2 interacting genes: ARHGDIA CD8B
Entrez ID		926	6484
HPRD ID		01725	00084
Ensembl ID		ENSG00000172116	ENSG00000110080
Uniprot IDs		P10966 Q53QL8	A0A7I2V5F3 A0A7P0RGI5 Q11206 Q6IBE6
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		T Cell Receptor Complex T Cell Receptor Signaling Pathway Cytotoxic T Cell Differentiation Antigen Receptor-mediated Signaling Pathway Beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide Alpha-2,3- Sialyltransferase N-acetyllactosaminide Alpha-2,3-sialyltransferase Activity Adaptive Immune Response Alpha-beta T Cell Receptor Complex Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway T Cell Activation MHC Class I Protein Complex Binding Beta-galactoside (CMP) Alpha-2,3-sialyltransferase Activity Positive T Cell Selection Positive Thymic T Cell Selection Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway External Side Of Plasma Membrane Activation Of Immune Response Regulation Of Immune System Process Regulation Of Leukocyte Tethering Or Rolling Positive Regulation Of Leukocyte Tethering Or Rolling Sialylation Keratan Sulfate Proteoglycan Biosynthetic Process Keratan Sulfate Proteoglycan Metabolic Process Lymphocyte Activation MHC Class I Protein Binding Sialyltransferase Activity Thymic T Cell Selection Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Oligosaccharide Biosynthetic Process Leukocyte Activation Positive Regulation Of Blood Coagulation T Cell Selection Viral Protein Processing Mitochondrial Small Ribosomal Subunit Positive Regulation Of Coagulation Positive Regulation Of Immune Response Cell Activation Plasma Membrane Raft T Cell Mediated Immunity Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Cellular Extravasation Protein O-linked Glycosylation Via N-acetyl-galactosamine Oligosaccharide Metabolic Process Coreceptor Activity Proteoglycan Biosynthetic Process Glycolipid Biosynthetic Process Golgi Cisterna Membrane Positive Regulation Of Wound Healing	Rho GDP-dissociation Inhibitor Activity Vitamin Binding Gamma-glutamyl Carboxylase Activity Negative Regulation Of Bone Development Negative Regulation Of Testosterone Biosynthetic Process Regulation Of Testosterone Biosynthetic Process Negative Regulation Of Neurotransmitter Secretion Regulation Of Bone Development Vitamin K Metabolic Process Regulation Of Synaptic Vesicle Cycle MHC Class I Protein Binding T Cell Receptor Complex Regulation Of Ketone Biosynthetic Process Negative Regulation Of Steroid Biosynthetic Process Negative Regulation Of Steroid Metabolic Process